The Calcium Culprit: A Case of Denosumab-induced Hypocalcemia

Denosumab is a fully human monoclonal antibody which is used to treat osteoporosis and has been shown to cause hypocalcemia in patients with underlying prostatic and bone malignancies, renal impairment, postmenopausal state, and/or vitamin D deficiency. We present a case of a male patient, with a pa...

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Detalles Bibliográficos
Autores principales: Kalayanamitra, Ricci, Yaghnam, Ibrahim, Patel, Ravi, Groff, Andrew, Jain, Rohit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663059/
https://www.ncbi.nlm.nih.gov/pubmed/31363449
http://dx.doi.org/10.7759/cureus.4768
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author Kalayanamitra, Ricci
Yaghnam, Ibrahim
Patel, Ravi
Groff, Andrew
Jain, Rohit
author_facet Kalayanamitra, Ricci
Yaghnam, Ibrahim
Patel, Ravi
Groff, Andrew
Jain, Rohit
author_sort Kalayanamitra, Ricci
collection PubMed
description Denosumab is a fully human monoclonal antibody which is used to treat osteoporosis and has been shown to cause hypocalcemia in patients with underlying prostatic and bone malignancies, renal impairment, postmenopausal state, and/or vitamin D deficiency. We present a case of a male patient, with a past medical history negative for the aforementioned conditions, who presented with right shoulder pain and was found to be severely hypocalcemic secondary to denosumab. 
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spelling pubmed-66630592019-07-30 The Calcium Culprit: A Case of Denosumab-induced Hypocalcemia Kalayanamitra, Ricci Yaghnam, Ibrahim Patel, Ravi Groff, Andrew Jain, Rohit Cureus Endocrinology/Diabetes/Metabolism Denosumab is a fully human monoclonal antibody which is used to treat osteoporosis and has been shown to cause hypocalcemia in patients with underlying prostatic and bone malignancies, renal impairment, postmenopausal state, and/or vitamin D deficiency. We present a case of a male patient, with a past medical history negative for the aforementioned conditions, who presented with right shoulder pain and was found to be severely hypocalcemic secondary to denosumab.  Cureus 2019-05-28 /pmc/articles/PMC6663059/ /pubmed/31363449 http://dx.doi.org/10.7759/cureus.4768 Text en Copyright © 2019, Kalayanamitra et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Kalayanamitra, Ricci
Yaghnam, Ibrahim
Patel, Ravi
Groff, Andrew
Jain, Rohit
The Calcium Culprit: A Case of Denosumab-induced Hypocalcemia
title The Calcium Culprit: A Case of Denosumab-induced Hypocalcemia
title_full The Calcium Culprit: A Case of Denosumab-induced Hypocalcemia
title_fullStr The Calcium Culprit: A Case of Denosumab-induced Hypocalcemia
title_full_unstemmed The Calcium Culprit: A Case of Denosumab-induced Hypocalcemia
title_short The Calcium Culprit: A Case of Denosumab-induced Hypocalcemia
title_sort calcium culprit: a case of denosumab-induced hypocalcemia
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663059/
https://www.ncbi.nlm.nih.gov/pubmed/31363449
http://dx.doi.org/10.7759/cureus.4768
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