Cargando…

Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin

Infection with enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea-related illness and death among children under 5 years of age in low– and middle-income countries (LMIC). Recent studies have found that it is the ETEC subtypes that produce the heat-stable enterotoxin (ST), irr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zegeye, Ephrem Debebe, Govasli, Morten Larsen, Sommerfelt, Halvor, Puntervoll, Pål
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663125/
https://www.ncbi.nlm.nih.gov/pubmed/30081709
http://dx.doi.org/10.1080/21645515.2018.1496768
_version_ 1783439769500385280
author Zegeye, Ephrem Debebe
Govasli, Morten Larsen
Sommerfelt, Halvor
Puntervoll, Pål
author_facet Zegeye, Ephrem Debebe
Govasli, Morten Larsen
Sommerfelt, Halvor
Puntervoll, Pål
author_sort Zegeye, Ephrem Debebe
collection PubMed
description Infection with enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea-related illness and death among children under 5 years of age in low– and middle-income countries (LMIC). Recent studies have found that it is the ETEC subtypes that produce the heat-stable enterotoxin (ST), irrespective of whether they also secrete the heat-labile enterotoxin (LT), which contribute most importantly to the disease burden in children from LMIC. Therefore, adding an ST toxoid would importantly complement ongoing ETEC vaccine development efforts. The ST’s potent toxicity, its structural similarity to the endogenous peptides guanylin and uroguanylin, and its poor immunogenicity have all complicated the advancement of ST-based vaccine development. Recent remarkable progress, however, including the unprecedented screening for optimal ST mutants, mapping of cross-reacting ST epitopes and improved ST-carrier coupling strategies (bioconjugation and genetic fusion), enables the rational design of safe, immunogenic, and well-defined ST-based vaccine candidates.
format Online
Article
Text
id pubmed-6663125
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-66631252019-08-05 Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin Zegeye, Ephrem Debebe Govasli, Morten Larsen Sommerfelt, Halvor Puntervoll, Pål Hum Vaccin Immunother Review Infection with enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea-related illness and death among children under 5 years of age in low– and middle-income countries (LMIC). Recent studies have found that it is the ETEC subtypes that produce the heat-stable enterotoxin (ST), irrespective of whether they also secrete the heat-labile enterotoxin (LT), which contribute most importantly to the disease burden in children from LMIC. Therefore, adding an ST toxoid would importantly complement ongoing ETEC vaccine development efforts. The ST’s potent toxicity, its structural similarity to the endogenous peptides guanylin and uroguanylin, and its poor immunogenicity have all complicated the advancement of ST-based vaccine development. Recent remarkable progress, however, including the unprecedented screening for optimal ST mutants, mapping of cross-reacting ST epitopes and improved ST-carrier coupling strategies (bioconjugation and genetic fusion), enables the rational design of safe, immunogenic, and well-defined ST-based vaccine candidates. Taylor & Francis 2018-08-21 /pmc/articles/PMC6663125/ /pubmed/30081709 http://dx.doi.org/10.1080/21645515.2018.1496768 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Zegeye, Ephrem Debebe
Govasli, Morten Larsen
Sommerfelt, Halvor
Puntervoll, Pål
Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin
title Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin
title_full Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin
title_fullStr Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin
title_full_unstemmed Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin
title_short Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin
title_sort development of an enterotoxigenic escherichia coli vaccine based on the heat-stable toxin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663125/
https://www.ncbi.nlm.nih.gov/pubmed/30081709
http://dx.doi.org/10.1080/21645515.2018.1496768
work_keys_str_mv AT zegeyeephremdebebe developmentofanenterotoxigenicescherichiacolivaccinebasedontheheatstabletoxin
AT govaslimortenlarsen developmentofanenterotoxigenicescherichiacolivaccinebasedontheheatstabletoxin
AT sommerfelthalvor developmentofanenterotoxigenicescherichiacolivaccinebasedontheheatstabletoxin
AT puntervollpal developmentofanenterotoxigenicescherichiacolivaccinebasedontheheatstabletoxin