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A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies
Enterotoxigenic Escherichia coli (ETEC) is a major cause of travelers’ diarrhea and of diarrhea among young children in developing countries. Experimental challenge studies in adult volunteers have played a pivotal role in establishing ETEC as an enteric pathogen, elucidating its pathogenesis by ide...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663128/ https://www.ncbi.nlm.nih.gov/pubmed/30724648 http://dx.doi.org/10.1080/21645515.2019.1578922 |
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author | Levine, Myron M. Barry, Eileen M. Chen, Wilbur H. |
author_facet | Levine, Myron M. Barry, Eileen M. Chen, Wilbur H. |
author_sort | Levine, Myron M. |
collection | PubMed |
description | Enterotoxigenic Escherichia coli (ETEC) is a major cause of travelers’ diarrhea and of diarrhea among young children in developing countries. Experimental challenge studies in adult volunteers have played a pivotal role in establishing ETEC as an enteric pathogen, elucidating its pathogenesis by identifying specific virulence attributes, characterizing the human immune response to clinical and sub-clinical ETEC infection and assessing preliminarily the clinical acceptability, immunogenicity and efficacy of prototype ETEC vaccines. This review provides a historical perspective of experimental challenge studies with ETEC. It summarizes pioneering early studies carried out by investigators at the University of Maryland School of Medicine to show how those studies provided key information that influenced the directions taken by many research groups to develop vaccines to prevent ETEC. In addition, key experimental challenge studies undertaken at other institutions will also be cited. |
format | Online Article Text |
id | pubmed-6663128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-66631282019-08-05 A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies Levine, Myron M. Barry, Eileen M. Chen, Wilbur H. Hum Vaccin Immunother Review Enterotoxigenic Escherichia coli (ETEC) is a major cause of travelers’ diarrhea and of diarrhea among young children in developing countries. Experimental challenge studies in adult volunteers have played a pivotal role in establishing ETEC as an enteric pathogen, elucidating its pathogenesis by identifying specific virulence attributes, characterizing the human immune response to clinical and sub-clinical ETEC infection and assessing preliminarily the clinical acceptability, immunogenicity and efficacy of prototype ETEC vaccines. This review provides a historical perspective of experimental challenge studies with ETEC. It summarizes pioneering early studies carried out by investigators at the University of Maryland School of Medicine to show how those studies provided key information that influenced the directions taken by many research groups to develop vaccines to prevent ETEC. In addition, key experimental challenge studies undertaken at other institutions will also be cited. Taylor & Francis 2019-03-20 /pmc/articles/PMC6663128/ /pubmed/30724648 http://dx.doi.org/10.1080/21645515.2019.1578922 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Review Levine, Myron M. Barry, Eileen M. Chen, Wilbur H. A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies |
title | A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies |
title_full | A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies |
title_fullStr | A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies |
title_full_unstemmed | A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies |
title_short | A roadmap for enterotoxigenic Escherichia coli vaccine development based on volunteer challenge studies |
title_sort | roadmap for enterotoxigenic escherichia coli vaccine development based on volunteer challenge studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663128/ https://www.ncbi.nlm.nih.gov/pubmed/30724648 http://dx.doi.org/10.1080/21645515.2019.1578922 |
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