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Growing Old Too Fast: A Rare Case of Werner Syndrome
Werner syndrome (WS) is rare adult-onset progeria characterized by premature aging and early death. Patients develop normally until adolescence and usually present in early adulthood. Our case highlights a common presentation of this uncommon disease, wherein a 29-year-old non-obese male with no kno...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663278/ https://www.ncbi.nlm.nih.gov/pubmed/31363425 http://dx.doi.org/10.7759/cureus.4743 |
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author | Kaur, Anahat Grover, Punita Albawaliz, Anas Chauhan, Mahak Barthel, Brandon |
author_facet | Kaur, Anahat Grover, Punita Albawaliz, Anas Chauhan, Mahak Barthel, Brandon |
author_sort | Kaur, Anahat |
collection | PubMed |
description | Werner syndrome (WS) is rare adult-onset progeria characterized by premature aging and early death. Patients develop normally until adolescence and usually present in early adulthood. Our case highlights a common presentation of this uncommon disease, wherein a 29-year-old non-obese male with no known risk factors developed uncontrolled diabetes, hypertriglyceridemia, and rapidly progressive atherosclerotic vascular disease. Careful observation with attention to the presence of characteristic physical features and subsequent genetic testing helped diagnose the patient with this uncommon progeroid syndrome. Our case adds to the literature about this rare disease especially in patients of middle-eastern descent and also highlights the importance of having a high index of suspicion for WS when the initial clinical presentation is atypical. |
format | Online Article Text |
id | pubmed-6663278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-66632782019-07-30 Growing Old Too Fast: A Rare Case of Werner Syndrome Kaur, Anahat Grover, Punita Albawaliz, Anas Chauhan, Mahak Barthel, Brandon Cureus Endocrinology/Diabetes/Metabolism Werner syndrome (WS) is rare adult-onset progeria characterized by premature aging and early death. Patients develop normally until adolescence and usually present in early adulthood. Our case highlights a common presentation of this uncommon disease, wherein a 29-year-old non-obese male with no known risk factors developed uncontrolled diabetes, hypertriglyceridemia, and rapidly progressive atherosclerotic vascular disease. Careful observation with attention to the presence of characteristic physical features and subsequent genetic testing helped diagnose the patient with this uncommon progeroid syndrome. Our case adds to the literature about this rare disease especially in patients of middle-eastern descent and also highlights the importance of having a high index of suspicion for WS when the initial clinical presentation is atypical. Cureus 2019-05-24 /pmc/articles/PMC6663278/ /pubmed/31363425 http://dx.doi.org/10.7759/cureus.4743 Text en Copyright © 2019, Kaur et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Endocrinology/Diabetes/Metabolism Kaur, Anahat Grover, Punita Albawaliz, Anas Chauhan, Mahak Barthel, Brandon Growing Old Too Fast: A Rare Case of Werner Syndrome |
title | Growing Old Too Fast: A Rare Case of Werner Syndrome |
title_full | Growing Old Too Fast: A Rare Case of Werner Syndrome |
title_fullStr | Growing Old Too Fast: A Rare Case of Werner Syndrome |
title_full_unstemmed | Growing Old Too Fast: A Rare Case of Werner Syndrome |
title_short | Growing Old Too Fast: A Rare Case of Werner Syndrome |
title_sort | growing old too fast: a rare case of werner syndrome |
topic | Endocrinology/Diabetes/Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663278/ https://www.ncbi.nlm.nih.gov/pubmed/31363425 http://dx.doi.org/10.7759/cureus.4743 |
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