Cargando…

Growing Old Too Fast: A Rare Case of Werner Syndrome

Werner syndrome (WS) is rare adult-onset progeria characterized by premature aging and early death. Patients develop normally until adolescence and usually present in early adulthood. Our case highlights a common presentation of this uncommon disease, wherein a 29-year-old non-obese male with no kno...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaur, Anahat, Grover, Punita, Albawaliz, Anas, Chauhan, Mahak, Barthel, Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663278/
https://www.ncbi.nlm.nih.gov/pubmed/31363425
http://dx.doi.org/10.7759/cureus.4743
_version_ 1783439776407355392
author Kaur, Anahat
Grover, Punita
Albawaliz, Anas
Chauhan, Mahak
Barthel, Brandon
author_facet Kaur, Anahat
Grover, Punita
Albawaliz, Anas
Chauhan, Mahak
Barthel, Brandon
author_sort Kaur, Anahat
collection PubMed
description Werner syndrome (WS) is rare adult-onset progeria characterized by premature aging and early death. Patients develop normally until adolescence and usually present in early adulthood. Our case highlights a common presentation of this uncommon disease, wherein a 29-year-old non-obese male with no known risk factors developed uncontrolled diabetes, hypertriglyceridemia, and rapidly progressive atherosclerotic vascular disease. Careful observation with attention to the presence of characteristic physical features and subsequent genetic testing helped diagnose the patient with this uncommon progeroid syndrome. Our case adds to the literature about this rare disease especially in patients of middle-eastern descent and also highlights the importance of having a high index of suspicion for WS when the initial clinical presentation is atypical.
format Online
Article
Text
id pubmed-6663278
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-66632782019-07-30 Growing Old Too Fast: A Rare Case of Werner Syndrome Kaur, Anahat Grover, Punita Albawaliz, Anas Chauhan, Mahak Barthel, Brandon Cureus Endocrinology/Diabetes/Metabolism Werner syndrome (WS) is rare adult-onset progeria characterized by premature aging and early death. Patients develop normally until adolescence and usually present in early adulthood. Our case highlights a common presentation of this uncommon disease, wherein a 29-year-old non-obese male with no known risk factors developed uncontrolled diabetes, hypertriglyceridemia, and rapidly progressive atherosclerotic vascular disease. Careful observation with attention to the presence of characteristic physical features and subsequent genetic testing helped diagnose the patient with this uncommon progeroid syndrome. Our case adds to the literature about this rare disease especially in patients of middle-eastern descent and also highlights the importance of having a high index of suspicion for WS when the initial clinical presentation is atypical. Cureus 2019-05-24 /pmc/articles/PMC6663278/ /pubmed/31363425 http://dx.doi.org/10.7759/cureus.4743 Text en Copyright © 2019, Kaur et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Kaur, Anahat
Grover, Punita
Albawaliz, Anas
Chauhan, Mahak
Barthel, Brandon
Growing Old Too Fast: A Rare Case of Werner Syndrome
title Growing Old Too Fast: A Rare Case of Werner Syndrome
title_full Growing Old Too Fast: A Rare Case of Werner Syndrome
title_fullStr Growing Old Too Fast: A Rare Case of Werner Syndrome
title_full_unstemmed Growing Old Too Fast: A Rare Case of Werner Syndrome
title_short Growing Old Too Fast: A Rare Case of Werner Syndrome
title_sort growing old too fast: a rare case of werner syndrome
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663278/
https://www.ncbi.nlm.nih.gov/pubmed/31363425
http://dx.doi.org/10.7759/cureus.4743
work_keys_str_mv AT kauranahat growingoldtoofastararecaseofwernersyndrome
AT groverpunita growingoldtoofastararecaseofwernersyndrome
AT albawalizanas growingoldtoofastararecaseofwernersyndrome
AT chauhanmahak growingoldtoofastararecaseofwernersyndrome
AT barthelbrandon growingoldtoofastararecaseofwernersyndrome