Co-existing of Neuromyelitis Optica and Fulminant Type 1 Diabetes

The patient was a 71-year-old woman with aquaporin-4-antibody positive neuromyelitis optica (NMO), with no history of diabetes. On admission, although she showed an extremely elevated plasma glucose level (1,080 mg/dL), her hemoglobin A1c level was low (7.1%), which indicated the rapid progression o...

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Detalles Bibliográficos
Autores principales: Saheki, Takanobu, Imachi, Hitomi, Ibata, Tomohiro, Fukunaga, Kensuke, Yoshioka, Yuki, Kobayashi, Toshihiro, Sato, Seisuke, Mizumoto, Kazuko, Yoshimoto, Takuo, Lyu, Jingya, Dong, Tao, Murao, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663534/
https://www.ncbi.nlm.nih.gov/pubmed/30918186
http://dx.doi.org/10.2169/internalmedicine.2353-18
Descripción
Sumario:The patient was a 71-year-old woman with aquaporin-4-antibody positive neuromyelitis optica (NMO), with no history of diabetes. On admission, although she showed an extremely elevated plasma glucose level (1,080 mg/dL), her hemoglobin A1c level was low (7.1%), which indicated the rapid progression of diabetes. She also showed ketoacidosis and had a human leukocyte antigen haplotype, DRB1*09:01-DQB1*03:03 associated with Fulminant type 1 diabetes (FT1D). Based on these results, the patient was diagnosed with FT1D. We herein describe the first reported case of a patient with FT1D with NMO, which raises the possibility that T-cell-mediated autoimmunity is involved in the pathogenesis of both FT1D and NMO.

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