An Autopsy Case of Bing-Neel Syndrome: Discrepancy between the Radiological and Pathological Findings

A 64-year-old man previously diagnosed with Waldenstrom's macroglobulinemia presented to our hospital with confusion. Magnetic resonance imaging (MRI) revealed diffuse meningeal enhancement. The patient was diagnosed with Bing-Neel syndrome (BNS) based on an elevated IgM index and the presence...

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Autores principales: Matsuda, Sakino, Sekiguchi, Naohiro, Ito, Kenichi, Takaoka, Ken, Furuki, Misako, Hirano, Kazuhiko, Obayashi, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663539/
https://www.ncbi.nlm.nih.gov/pubmed/30918173
http://dx.doi.org/10.2169/internalmedicine.1907-18
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author Matsuda, Sakino
Sekiguchi, Naohiro
Ito, Kenichi
Takaoka, Ken
Furuki, Misako
Hirano, Kazuhiko
Obayashi, Masato
author_facet Matsuda, Sakino
Sekiguchi, Naohiro
Ito, Kenichi
Takaoka, Ken
Furuki, Misako
Hirano, Kazuhiko
Obayashi, Masato
author_sort Matsuda, Sakino
collection PubMed
description A 64-year-old man previously diagnosed with Waldenstrom's macroglobulinemia presented to our hospital with confusion. Magnetic resonance imaging (MRI) revealed diffuse meningeal enhancement. The patient was diagnosed with Bing-Neel syndrome (BNS) based on an elevated IgM index and the presence of monoclonal IgM protein, as detected by immunofixation electrophoresis of the cerebrospinal fluid. The patient underwent intrathecal and systemic chemotherapy but ultimately died of pneumonia. An autopsy revealed extensive meningeal and perivascular infiltration by malignant cells throughout the brain and spine. Thus, BNS may cause more extensive malignant infiltration into the central nervous system than is revealed by MRI.
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spelling pubmed-66635392019-07-29 An Autopsy Case of Bing-Neel Syndrome: Discrepancy between the Radiological and Pathological Findings Matsuda, Sakino Sekiguchi, Naohiro Ito, Kenichi Takaoka, Ken Furuki, Misako Hirano, Kazuhiko Obayashi, Masato Intern Med Case Report A 64-year-old man previously diagnosed with Waldenstrom's macroglobulinemia presented to our hospital with confusion. Magnetic resonance imaging (MRI) revealed diffuse meningeal enhancement. The patient was diagnosed with Bing-Neel syndrome (BNS) based on an elevated IgM index and the presence of monoclonal IgM protein, as detected by immunofixation electrophoresis of the cerebrospinal fluid. The patient underwent intrathecal and systemic chemotherapy but ultimately died of pneumonia. An autopsy revealed extensive meningeal and perivascular infiltration by malignant cells throughout the brain and spine. Thus, BNS may cause more extensive malignant infiltration into the central nervous system than is revealed by MRI. The Japanese Society of Internal Medicine 2019-03-28 2019-07-01 /pmc/articles/PMC6663539/ /pubmed/30918173 http://dx.doi.org/10.2169/internalmedicine.1907-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Matsuda, Sakino
Sekiguchi, Naohiro
Ito, Kenichi
Takaoka, Ken
Furuki, Misako
Hirano, Kazuhiko
Obayashi, Masato
An Autopsy Case of Bing-Neel Syndrome: Discrepancy between the Radiological and Pathological Findings
title An Autopsy Case of Bing-Neel Syndrome: Discrepancy between the Radiological and Pathological Findings
title_full An Autopsy Case of Bing-Neel Syndrome: Discrepancy between the Radiological and Pathological Findings
title_fullStr An Autopsy Case of Bing-Neel Syndrome: Discrepancy between the Radiological and Pathological Findings
title_full_unstemmed An Autopsy Case of Bing-Neel Syndrome: Discrepancy between the Radiological and Pathological Findings
title_short An Autopsy Case of Bing-Neel Syndrome: Discrepancy between the Radiological and Pathological Findings
title_sort autopsy case of bing-neel syndrome: discrepancy between the radiological and pathological findings
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663539/
https://www.ncbi.nlm.nih.gov/pubmed/30918173
http://dx.doi.org/10.2169/internalmedicine.1907-18
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