IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes

An 83-year-old man with stable chronic kidney disease (CKD) exhibited a sudden increase in urinary N-acetyl-β-D-glucosaminidase and protein excretion, suggesting aggravated kidney damage. Simultaneously, he lost diabetic control, requiring up to 54 units of insulin daily. A detailed examination reve...

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Detalles Bibliográficos
Autores principales: Okada, Akira, Higashihara, Takaaki, Kusano, Taiko, Takemura, Koji, Saigusa, Hanako, Maruno, Sayako, Matsumura, Mimiko, Suzuki, Takeo, Shimizu, Akira, Takano, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663549/
https://www.ncbi.nlm.nih.gov/pubmed/30918174
http://dx.doi.org/10.2169/internalmedicine.2000-18
Descripción
Sumario:An 83-year-old man with stable chronic kidney disease (CKD) exhibited a sudden increase in urinary N-acetyl-β-D-glucosaminidase and protein excretion, suggesting aggravated kidney damage. Simultaneously, he lost diabetic control, requiring up to 54 units of insulin daily. A detailed examination revealed the presence of renal cell carcinoma, which was surgically resected and confirmed to be interleukin-6-positive by immunohistochemistry. Postoperatively, his uni-nephrectomy necessitated hemodialysis, but the patient’s insulin resistance was ameliorated; no medication was required to control diabetes, suggesting that the tumor had caused the insulin resistance. This report describes a case of a tumor secreting interleukin-6, which affects both the control of diabetes and CKD progression.

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