IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes

An 83-year-old man with stable chronic kidney disease (CKD) exhibited a sudden increase in urinary N-acetyl-β-D-glucosaminidase and protein excretion, suggesting aggravated kidney damage. Simultaneously, he lost diabetic control, requiring up to 54 units of insulin daily. A detailed examination reve...

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Autores principales: Okada, Akira, Higashihara, Takaaki, Kusano, Taiko, Takemura, Koji, Saigusa, Hanako, Maruno, Sayako, Matsumura, Mimiko, Suzuki, Takeo, Shimizu, Akira, Takano, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663549/
https://www.ncbi.nlm.nih.gov/pubmed/30918174
http://dx.doi.org/10.2169/internalmedicine.2000-18
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author Okada, Akira
Higashihara, Takaaki
Kusano, Taiko
Takemura, Koji
Saigusa, Hanako
Maruno, Sayako
Matsumura, Mimiko
Suzuki, Takeo
Shimizu, Akira
Takano, Hideki
author_facet Okada, Akira
Higashihara, Takaaki
Kusano, Taiko
Takemura, Koji
Saigusa, Hanako
Maruno, Sayako
Matsumura, Mimiko
Suzuki, Takeo
Shimizu, Akira
Takano, Hideki
author_sort Okada, Akira
collection PubMed
description An 83-year-old man with stable chronic kidney disease (CKD) exhibited a sudden increase in urinary N-acetyl-β-D-glucosaminidase and protein excretion, suggesting aggravated kidney damage. Simultaneously, he lost diabetic control, requiring up to 54 units of insulin daily. A detailed examination revealed the presence of renal cell carcinoma, which was surgically resected and confirmed to be interleukin-6-positive by immunohistochemistry. Postoperatively, his uni-nephrectomy necessitated hemodialysis, but the patient’s insulin resistance was ameliorated; no medication was required to control diabetes, suggesting that the tumor had caused the insulin resistance. This report describes a case of a tumor secreting interleukin-6, which affects both the control of diabetes and CKD progression.
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spelling pubmed-66635492019-07-29 IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes Okada, Akira Higashihara, Takaaki Kusano, Taiko Takemura, Koji Saigusa, Hanako Maruno, Sayako Matsumura, Mimiko Suzuki, Takeo Shimizu, Akira Takano, Hideki Intern Med Case Report An 83-year-old man with stable chronic kidney disease (CKD) exhibited a sudden increase in urinary N-acetyl-β-D-glucosaminidase and protein excretion, suggesting aggravated kidney damage. Simultaneously, he lost diabetic control, requiring up to 54 units of insulin daily. A detailed examination revealed the presence of renal cell carcinoma, which was surgically resected and confirmed to be interleukin-6-positive by immunohistochemistry. Postoperatively, his uni-nephrectomy necessitated hemodialysis, but the patient’s insulin resistance was ameliorated; no medication was required to control diabetes, suggesting that the tumor had caused the insulin resistance. This report describes a case of a tumor secreting interleukin-6, which affects both the control of diabetes and CKD progression. The Japanese Society of Internal Medicine 2019-03-28 2019-07-01 /pmc/articles/PMC6663549/ /pubmed/30918174 http://dx.doi.org/10.2169/internalmedicine.2000-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Okada, Akira
Higashihara, Takaaki
Kusano, Taiko
Takemura, Koji
Saigusa, Hanako
Maruno, Sayako
Matsumura, Mimiko
Suzuki, Takeo
Shimizu, Akira
Takano, Hideki
IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes
title IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes
title_full IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes
title_fullStr IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes
title_full_unstemmed IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes
title_short IL-6-producing Renal Cell Carcinoma Causing Renal and Endocrine Paraneoplastic Syndromes
title_sort il-6-producing renal cell carcinoma causing renal and endocrine paraneoplastic syndromes
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663549/
https://www.ncbi.nlm.nih.gov/pubmed/30918174
http://dx.doi.org/10.2169/internalmedicine.2000-18
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