Cargando…

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6

JmjC domain-containing protein 6 (JMJD6) is a 2-oxoglutarate (2OG)-dependent oxygenase linked to various cellular processes, including splicing regulation, histone modification, transcriptional pause release, hypoxia sensing, and cancer. JMJD6 is reported to catalyze hydroxylation of lysine residue(...

Descripción completa

Detalles Bibliográficos
Autores principales:	Islam, Md. Saiful, McDonough, Michael A., Chowdhury, Rasheduzzaman, Gault, Joseph, Khan, Amjad, Pires, Elisabete, Schofield, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663879/ https://www.ncbi.nlm.nih.gov/pubmed/31147442 http://dx.doi.org/10.1074/jbc.RA119.008693

Ejemplares similares

Structural analysis of the 2-oxoglutarate binding site of the circadian rhythm linked oxygenase JMJD5
por: Islam, Md. Saiful, et al.
Publicado: (2022)

Inhibition of JMJD6 by 2‐Oxoglutarate Mimics
por: Islam, Md. Sailful, et al.
Publicado: (2021)

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
por: Liu, Tongri, et al.
Publicado: (2021)

JMJD5 is a human arginyl C-3 hydroxylase
por: Wilkins, Sarah E., et al.
Publicado: (2018)

The mechanism of a one-substrate transketolase reaction
por: Solovjeva, Olga N., et al.
Publicado: (2020)

Probing altered enzyme activity in the biochemical characterization of cancer
por: Adam, Mowaffaq Adam Ahmed, et al.
Publicado: (2022)

Proteomic discovery of substrates of the cardiovascular protease ADAMTS7
por: Colige, Alain, et al.
Publicado: (2019)

Publisher Correction: JMJD5 is a human arginyl C-3 hydroxylase
por: Wilkins, Sarah E., et al.
Publicado: (2018)

Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Reveals in Vivo Roles in Cellular Homeostasis and Energy Metabolism
por: Wilson, Claire H., et al.
Publicado: (2013)

Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases
por: Malcolm, Tess R., et al.
Publicado: (2021)

Reducing Agent‐Mediated Nonenzymatic Conversion of 2‐Oxoglutarate to Succinate: Implications for Oxygenase Assays
por: Khan, Amjad, et al.
Publicado: (2020)

Ascertaining the biochemical function of an essential pectin methylesterase in the gut microbe Bacteroides thetaiotaomicron
por: Duan, Cheng-Jie, et al.
Publicado: (2021)

Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases
por: Markolovic, Suzana, et al.
Publicado: (2015)

Resurrection of ancestral effector caspases identifies novel networks for evolution of substrate specificity
por: Grinshpon, Robert D., et al.
Publicado: (2019)

Substrate Oxidation by Indoleamine 2,3-Dioxygenase: EVIDENCE FOR A COMMON REACTION MECHANISM
por: Booth, Elizabeth S., et al.
Publicado: (2015)

Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human Macrophages
por: Kennedy, Edward M., et al.
Publicado: (2010)

Structural and biochemical insights into the catalytic mechanisms of two insect chitin deacetylases of the carbohydrate esterase 4 family
por: Liu, Lin, et al.
Publicado: (2019)

Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing
por: Brewitz, Lennart, et al.
Publicado: (2020)

Proline Scanning Mutagenesis Reveals a Role for the Flap Endonuclease-1 Helical Cap in Substrate Unpairing
por: Patel, Nikesh, et al.
Publicado: (2013)

Structural analyses of Arabidopsis thaliana legumain γ reveal differential recognition and processing of proteolysis and ligation substrates
por: Zauner, Florian B., et al.
Publicado: (2018)

Active-site copper reduction promotes substrate binding of fungal lytic polysaccharide monooxygenase and reduces stability
por: Kracher, Daniel, et al.
Publicado: (2018)

Structural and biochemical studies of the glucuronoyl esterase OtCE15A illuminate its interaction with lignocellulosic components
por: Mazurkewich, Scott, et al.
Publicado: (2019)

Regulated Phosphorylation of a Major UDP-glucuronosyltransferase Isozyme by Tyrosine Kinases Dictates Endogenous Substrate Selection for Detoxification
por: Mitra, Partha S., et al.
Publicado: (2011)

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
por: Waz, Shaimaa, et al.
Publicado: (2017)

Pre-steady-state Kinetics Reveal the Substrate Specificity and Mechanism of Halide Oxidation of Truncated Human Peroxidasin 1
por: Paumann-Page, Martina, et al.
Publicado: (2017)

Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches
por: Fernandes, Peter M., et al.
Publicado: (2020)

Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family
por: Schwander, Thomas, et al.
Publicado: (2018)

Investigating the reaction and substrate preference of indole-3-acetaldehyde dehydrogenase from the plant pathogen Pseudomonas syringae PtoDC3000
por: Zhang, Kaleena, et al.
Publicado: (2020)

Roles of Phosphate Recognition in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase (IPK1) Substrate Binding and Activation
por: Gosein, Varin, et al.
Publicado: (2013)

Urinary l-erythro-β-hydroxyasparagine—a novel serine racemase inhibitor and substrate of the Zn(2+)-dependent d-serine dehydratase
por: Ito, Tomokazu, et al.
Publicado: (2021)

Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism
por: Aertker, Kristina M.J., et al.
Publicado: (2021)

GUCY2D mutations in retinal guanylyl cyclase 1 provide biochemical reasons for dominant cone–rod dystrophy but not for stationary night blindness
por: Peshenko, Igor V., et al.
Publicado: (2021)

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein from Enterococcus faecalis and Crystal Structure of the Activator-Substrate Complex
por: Vorontsov, Ivan I., et al.
Publicado: (2011)

The Catalytic Aspartate Is Protonated in the Michaelis Complex Formed between Trypsin and an in Vitro Evolved Substrate-like Inhibitor: A REFINED MECHANISM OF SERINE PROTEASE ACTION
por: Wahlgren, Weixiao Yuan, et al.
Publicado: (2011)

Comparative Analysis of Histophilus somni Immunoglobulin-binding Protein A (IbpA) with Other Fic Domain-containing Enzymes Reveals Differences in Substrate and Nucleotide Specificities
por: Mattoo, Seema, et al.
Publicado: (2011)

Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism
por: Emberley, Ethan D., et al.
Publicado: (2012)

Human UTY(KDM6C) Is a Male-specific N(ϵ)-Methyl Lysyl Demethylase
por: Walport, Louise J., et al.
Publicado: (2014)

Human Oxygenase Variants Employing a Single Protein Fe(II) Ligand Are Catalytically Active
por: Brasnett, Amelia, et al.
Publicado: (2021)

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor
por: Tarhonskaya, Hanna, et al.
Publicado: (2015)

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases
por: Sengerová, Blanka, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_17qjhac82sdp5fld1df5oakqqd