A Novel Phytochemical, DIM, Inhibits Proliferation, Migration, Invasion and TNF-α Induced Inflammatory Cytokine Production of Synovial Fibroblasts From Rheumatoid Arthritis Patients by Targeting MAPK and AKT/mTOR Signal Pathway

In rheumatoid arthritis(RA) pathogenesis, activated RA fibroblast-like synoviocytes (RA-FLSs) exhibit similar proliferative features as tumor cells and subsequent erosion to cartilage will eventually lead to joint destruction. Therefore, it is imperative to search for compounds, which can effectivel...

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Detalles Bibliográficos
Autores principales: Du, Hongyan, Zhang, Xi, Zeng, Yongchang, Huang, Xiaoming, Chen, Hao, Wang, Suihai, Wu, Jing, Li, Qiang, Zhu, Wei, Li, Hongwei, Liu, Tiancai, Yu, Qinghong, Wu, Yingsong, Jie, Ligang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663984/
https://www.ncbi.nlm.nih.gov/pubmed/31396207
http://dx.doi.org/10.3389/fimmu.2019.01620

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