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Insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease

Lack of insulin or insulin resistance (IR) plays a central role in diabetes mellitus and makes diabetics prone to acute ischemic heart disease (AIHD). It has likewise been found that many cancer patients, including prostate cancer patients die of AIHD. Previously it has been delineated from our labo...

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Autores principales: Ray, Udayan, Bank, Sarbashri, Jayawardana, Madawa W., Bhowmik, Jahar, Redwig, Frank, Jana, Pradipta, Bhattacharya, Suman, Manna, Emili, Kumar De, Subrata, Maiti, Smarajit, Roberts-Thomson, Philip, Parameswaran, Venkat, Sinha, Asru K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663988/
https://www.ncbi.nlm.nih.gov/pubmed/31300527
http://dx.doi.org/10.1042/BSR20182313
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author Ray, Udayan
Bank, Sarbashri
Jayawardana, Madawa W.
Bhowmik, Jahar
Redwig, Frank
Jana, Pradipta
Bhattacharya, Suman
Manna, Emili
Kumar De, Subrata
Maiti, Smarajit
Roberts-Thomson, Philip
Parameswaran, Venkat
Sinha, Asru K.
author_facet Ray, Udayan
Bank, Sarbashri
Jayawardana, Madawa W.
Bhowmik, Jahar
Redwig, Frank
Jana, Pradipta
Bhattacharya, Suman
Manna, Emili
Kumar De, Subrata
Maiti, Smarajit
Roberts-Thomson, Philip
Parameswaran, Venkat
Sinha, Asru K.
author_sort Ray, Udayan
collection PubMed
description Lack of insulin or insulin resistance (IR) plays a central role in diabetes mellitus and makes diabetics prone to acute ischemic heart disease (AIHD). It has likewise been found that many cancer patients, including prostate cancer patients die of AIHD. Previously it has been delineated from our laboratory that dermcidin could induce anomalous platelet aggregation in AIHD and also impaired nitric oxide and insulin activity and furthermore dermcidin was also found in a few types of cancer patients. To determine the role of this protein in prostatic malignancy, a retrospective case–control study was conducted and blood was collected from prostate cancer patients and healthy normal volunteers. So, we measured the level of dermcidin protein and analyzed the IR by Homeostasis Model Assessment (HOMA) score calculation. Nitric oxide was measured by methemoglobin method. HDL, glycated hemoglobin (HbA1c), BMI, hs-cTroponin-T were measured for the validation of the patients’ status in the presence of Dermcidin isoform-2 (DCN-2). Multiple logistic regression model adjusted for age and BMI identified that the HOMA score was significantly elevated in prostate cancer patients (OR = 7.19, P<0.001). Prostate cancer patients are associated with lower level of NO and higher level of both proteins dermcidin (OR = 1.12, P<0.001) and hs-TroponinT (OR = 1.76, P<0.001). From the results, it can be interpreted that IR plays a key role in the pathophysiology of prostate cancer where dermcidin was the cause of IR through NO inhibition leading to AIHD was also explained by high-sensitive fifth generation cTroponin-T (hs-cTroponinT) and HbA1c level which are associated with endothelial dysfunction.
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spelling pubmed-66639882019-07-31 Insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease Ray, Udayan Bank, Sarbashri Jayawardana, Madawa W. Bhowmik, Jahar Redwig, Frank Jana, Pradipta Bhattacharya, Suman Manna, Emili Kumar De, Subrata Maiti, Smarajit Roberts-Thomson, Philip Parameswaran, Venkat Sinha, Asru K. Biosci Rep Research Articles Lack of insulin or insulin resistance (IR) plays a central role in diabetes mellitus and makes diabetics prone to acute ischemic heart disease (AIHD). It has likewise been found that many cancer patients, including prostate cancer patients die of AIHD. Previously it has been delineated from our laboratory that dermcidin could induce anomalous platelet aggregation in AIHD and also impaired nitric oxide and insulin activity and furthermore dermcidin was also found in a few types of cancer patients. To determine the role of this protein in prostatic malignancy, a retrospective case–control study was conducted and blood was collected from prostate cancer patients and healthy normal volunteers. So, we measured the level of dermcidin protein and analyzed the IR by Homeostasis Model Assessment (HOMA) score calculation. Nitric oxide was measured by methemoglobin method. HDL, glycated hemoglobin (HbA1c), BMI, hs-cTroponin-T were measured for the validation of the patients’ status in the presence of Dermcidin isoform-2 (DCN-2). Multiple logistic regression model adjusted for age and BMI identified that the HOMA score was significantly elevated in prostate cancer patients (OR = 7.19, P<0.001). Prostate cancer patients are associated with lower level of NO and higher level of both proteins dermcidin (OR = 1.12, P<0.001) and hs-TroponinT (OR = 1.76, P<0.001). From the results, it can be interpreted that IR plays a key role in the pathophysiology of prostate cancer where dermcidin was the cause of IR through NO inhibition leading to AIHD was also explained by high-sensitive fifth generation cTroponin-T (hs-cTroponinT) and HbA1c level which are associated with endothelial dysfunction. Portland Press Ltd. 2019-07-29 /pmc/articles/PMC6663988/ /pubmed/31300527 http://dx.doi.org/10.1042/BSR20182313 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Ray, Udayan
Bank, Sarbashri
Jayawardana, Madawa W.
Bhowmik, Jahar
Redwig, Frank
Jana, Pradipta
Bhattacharya, Suman
Manna, Emili
Kumar De, Subrata
Maiti, Smarajit
Roberts-Thomson, Philip
Parameswaran, Venkat
Sinha, Asru K.
Insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease
title Insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease
title_full Insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease
title_fullStr Insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease
title_full_unstemmed Insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease
title_short Insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease
title_sort insulin resistance in prostate cancer patients and predisposing them to acute ischemic heart disease
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663988/
https://www.ncbi.nlm.nih.gov/pubmed/31300527
http://dx.doi.org/10.1042/BSR20182313
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