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(Pro)renin Receptor-Dependent Induction of Profibrotic Factors Is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Collecting Duct Cells

The binding of prorenin to the (pro)renin receptor (PRR) triggers the activation of MAPK/ERK1/2 pathway, induction of cyclooxygenase-2 (COX-2), NOX-4-dependent production of reactive oxygen species (ROS), and the induction of transforming growth factor β (TGF-β) and profibrotic factors connecting ti...

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Detalles Bibliográficos
Autores principales:	Reyes-Martinez, Cristian, Nguyen, Quynh My, Kassan, Modar, Gonzalez, Alexis A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664006/ https://www.ncbi.nlm.nih.gov/pubmed/31396082 http://dx.doi.org/10.3389/fphar.2019.00803

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