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Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL

PINK1 (PARK6) and PARKIN (PARK2) are causal genes of recessive familial Parkinson's disease. Parkin is a ubiquitin ligase E3 that conjugates ubiquitin to impaired mitochondrial proteins for organelle degradation. PINK1, a Ser/Thr kinase that accumulates only on impaired mitochondria, phosphoryl...

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Detalles Bibliográficos
Autores principales:	Koyano, Fumika, Yamano, Koji, Kosako, Hidetaka, Tanaka, Keiji, Matsuda, Noriyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664184/ https://www.ncbi.nlm.nih.gov/pubmed/31110043 http://dx.doi.org/10.1074/jbc.RA118.006302

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