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Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment
OBJECTIVE: This study aimed to examine the association between normal-but-low folate levels and cognitive function in the elderly population using a prospective cohort study. METHODS: We analyzed 3,910 participants whose serum folate levels were within the normal reference range (1.5–16.9 ng/mL) at...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Neuropsychiatric Association
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664218/ https://www.ncbi.nlm.nih.gov/pubmed/31352735 http://dx.doi.org/10.30773/pi.2019.05.29 |
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author | Jang, Soomin Han, Ji Won Shin, Jiyoon Kim, Tae Hui Kwak, Kyung Phil Kim, Kayoung Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hyun Moon, Seok Woo Park, Jae Young Park, Joon Hyuk Byun, Seonjeong Suh, Seung Wan Seo, Jiyeong So, Yoonseop Ryu, Seung-Ho Youn, Jong Chul Lee, Kyoung Hwan Lee, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Ju Ri Jeong, Hyeon Jeong, Hyun-Ghang Jhoo, Jin Hyeong Han, Kyuhee Hong, Jong Woo Kim, Ki Woong |
author_facet | Jang, Soomin Han, Ji Won Shin, Jiyoon Kim, Tae Hui Kwak, Kyung Phil Kim, Kayoung Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hyun Moon, Seok Woo Park, Jae Young Park, Joon Hyuk Byun, Seonjeong Suh, Seung Wan Seo, Jiyeong So, Yoonseop Ryu, Seung-Ho Youn, Jong Chul Lee, Kyoung Hwan Lee, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Ju Ri Jeong, Hyeon Jeong, Hyun-Ghang Jhoo, Jin Hyeong Han, Kyuhee Hong, Jong Woo Kim, Ki Woong |
author_sort | Jang, Soomin |
collection | PubMed |
description | OBJECTIVE: This study aimed to examine the association between normal-but-low folate levels and cognitive function in the elderly population using a prospective cohort study. METHODS: We analyzed 3,910 participants whose serum folate levels were within the normal reference range (1.5–16.9 ng/mL) at baseline evaluation in the population-based prospective cohort study named the “Korean Longitudinal Study on Cognitive Aging and Dementia.” The association between baseline folate quartile categories and baseline cognitive disorders [mild cognitive impairment (MCI) or dementia] was examined using binary logistic regression analysis adjusting for confounding variables. The risks of incident MCI and dementia associated with the decline of serum folate level during a 4-year follow-up period were examined using multinomial logistic regression analysis. RESULTS: The lowest quartile group of serum folate (≥1.5, ≤5.9 ng/mL) showed a higher risk of cognitive disorders than did the highest quartile group at baseline evaluation (odds ratio 1.314, p=0.012). Over the 4 years of follow-up, the risk of incident dementia was 2.364 times higher among subjects whose serum folate levels declined from the 2nd–4th quartile group to the 1st quartile than among those for whom it did not (p=0.031). CONCLUSION: Normal-but-low serum folate levels were associated with the risk of cognitive disorders in the elderly population, and a decline to normal-but-low serum folate levels was associated with incident dementia. Maintaining serum folate concentration above 5.9 ng/mL may be beneficial for cognitive status. |
format | Online Article Text |
id | pubmed-6664218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Neuropsychiatric Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-66642182019-07-31 Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment Jang, Soomin Han, Ji Won Shin, Jiyoon Kim, Tae Hui Kwak, Kyung Phil Kim, Kayoung Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hyun Moon, Seok Woo Park, Jae Young Park, Joon Hyuk Byun, Seonjeong Suh, Seung Wan Seo, Jiyeong So, Yoonseop Ryu, Seung-Ho Youn, Jong Chul Lee, Kyoung Hwan Lee, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Ju Ri Jeong, Hyeon Jeong, Hyun-Ghang Jhoo, Jin Hyeong Han, Kyuhee Hong, Jong Woo Kim, Ki Woong Psychiatry Investig Original Article OBJECTIVE: This study aimed to examine the association between normal-but-low folate levels and cognitive function in the elderly population using a prospective cohort study. METHODS: We analyzed 3,910 participants whose serum folate levels were within the normal reference range (1.5–16.9 ng/mL) at baseline evaluation in the population-based prospective cohort study named the “Korean Longitudinal Study on Cognitive Aging and Dementia.” The association between baseline folate quartile categories and baseline cognitive disorders [mild cognitive impairment (MCI) or dementia] was examined using binary logistic regression analysis adjusting for confounding variables. The risks of incident MCI and dementia associated with the decline of serum folate level during a 4-year follow-up period were examined using multinomial logistic regression analysis. RESULTS: The lowest quartile group of serum folate (≥1.5, ≤5.9 ng/mL) showed a higher risk of cognitive disorders than did the highest quartile group at baseline evaluation (odds ratio 1.314, p=0.012). Over the 4 years of follow-up, the risk of incident dementia was 2.364 times higher among subjects whose serum folate levels declined from the 2nd–4th quartile group to the 1st quartile than among those for whom it did not (p=0.031). CONCLUSION: Normal-but-low serum folate levels were associated with the risk of cognitive disorders in the elderly population, and a decline to normal-but-low serum folate levels was associated with incident dementia. Maintaining serum folate concentration above 5.9 ng/mL may be beneficial for cognitive status. Korean Neuropsychiatric Association 2019-07 2019-07-25 /pmc/articles/PMC6664218/ /pubmed/31352735 http://dx.doi.org/10.30773/pi.2019.05.29 Text en Copyright © 2019 Korean Neuropsychiatric Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Jang, Soomin Han, Ji Won Shin, Jiyoon Kim, Tae Hui Kwak, Kyung Phil Kim, Kayoung Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hyun Moon, Seok Woo Park, Jae Young Park, Joon Hyuk Byun, Seonjeong Suh, Seung Wan Seo, Jiyeong So, Yoonseop Ryu, Seung-Ho Youn, Jong Chul Lee, Kyoung Hwan Lee, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Ju Ri Jeong, Hyeon Jeong, Hyun-Ghang Jhoo, Jin Hyeong Han, Kyuhee Hong, Jong Woo Kim, Ki Woong Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment |
title | Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment |
title_full | Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment |
title_fullStr | Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment |
title_full_unstemmed | Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment |
title_short | Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment |
title_sort | normal-but-low serum folate levels and the risks for cognitive impairment |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664218/ https://www.ncbi.nlm.nih.gov/pubmed/31352735 http://dx.doi.org/10.30773/pi.2019.05.29 |
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