Diffusion kurtosis and quantitative susceptibility mapping MRI are sensitive to structural abnormalities in amyotrophic lateral sclerosis

OBJECTIVE: To construct a clinical diagnostic biomarker using state-of-the-art microstructural MRI in the motor cortex of people with amyotrophic lateral sclerosis (ALS). METHODS: Clinical and MRI data were obtained from 21 ALS patients (aged 54 ± 14 years, 33% female) and 63 age- and gender-matched...

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Detalles Bibliográficos
Autores principales: Welton, Thomas, Maller, Jerome J., Lebel, R. Marc, Tan, Ek T., Rowe, Dominic B., Grieve, Stuart M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664242/
https://www.ncbi.nlm.nih.gov/pubmed/31357149
http://dx.doi.org/10.1016/j.nicl.2019.101953

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