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Synthesis of 9-O-arylated berberines via copper-catalyzed C(Ar)–O coupling reactions
Berberine is a widely used antimicrobial agent in clinic. However, a high dosage is often required due to its low lipophilicity and bioavailability. The current study explores the structural modifications of berberines with potentially lipophilic aryl groups to address this problem. A series of 15 9...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664384/ https://www.ncbi.nlm.nih.gov/pubmed/31435439 http://dx.doi.org/10.3762/bjoc.15.161 |