Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness

BACKGROUND: Metabolic syndrome, an obesity-related condition associated with insulin resistance and low-grade inflammation, leads to diabetes, cardiovascular diseases, cancer, osteoarthritis, and other disorders. Optimal therapy is unknown. The antimalarial drug chloroquine activates the kinase atax...

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Detalles Bibliográficos
Autores principales: McGill, Janet B., Johnson, Mariko, Hurst, Stacy, Cade, William T., Yarasheski, Kevin E., Ostlund, Richard E., Schechtman, Kenneth B., Razani, Babak, Kastan, Michael B., McClain, Donald A., de las Fuentes, Lisa, Davila-Roman, Victor G., Ory, Daniel S., Wickline, Samuel A., Semenkovich, Clay F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664523/
https://www.ncbi.nlm.nih.gov/pubmed/31384309
http://dx.doi.org/10.1186/s13098-019-0456-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664523/
https://www.ncbi.nlm.nih.gov/pubmed/31384309
http://dx.doi.org/10.1186/s13098-019-0456-4

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