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Risk factors for the formation of double-contour sign and tophi in gout
BACKGROUND: This study aimed to confirm the diagnostic accuracy of ultrasound (US) on gout and explore the potential risk factors for double-contour sign and tophi formation in gout patients. METHODS: The US analyses were performed on all knee, ankle, and first metatarsophalangeal (MTP 1) joints to...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664526/ https://www.ncbi.nlm.nih.gov/pubmed/31358044 http://dx.doi.org/10.1186/s13018-019-1280-0 |
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author | Sun, Chao Qi, Xuan Tian, Yu Gao, Lixia Jin, Hongtao Guo, Huifang |
author_facet | Sun, Chao Qi, Xuan Tian, Yu Gao, Lixia Jin, Hongtao Guo, Huifang |
author_sort | Sun, Chao |
collection | PubMed |
description | BACKGROUND: This study aimed to confirm the diagnostic accuracy of ultrasound (US) on gout and explore the potential risk factors for double-contour sign and tophi formation in gout patients. METHODS: The US analyses were performed on all knee, ankle, and first metatarsophalangeal (MTP 1) joints to reveal the type and location of lesions. While a questionnaire and blood biochemical index were used to explore the potential risk factors for double-contour sign and tophi in gout, the SPSS17.0 software was used for statistical analysis in the present study. RESULTS: Totally, 117 gout patients with 702 joints (38 lesions in knee joint, 93 lesions in ankle joint, and 112 lesions in MTP 1 joint) were enrolled in current analyses. Double-contour sign and joint effusion were the two most outstanding lesion manifestations in knee joints and ankle joints. Tophi and double-contour sign were the two most outstanding lesion manifestations in TMP 1 joints. Moreover, factors including uric acid (UA) level and the highest blood UA were potential risk factors of the double-contour sign, while age and history of US were potential risk factors for tophi. CONCLUSION: US was effective on the joints of gout patients. There was US sensitivity for tophi and double-contour sign in MTP 1 joints. The double-contour sign was a potential specific manifestation in knee joints and ankle joints. Furthermore, UA and highest blood UA level were potential risk factors for double-contour sign, while age and US history were potential risk factors for tophi. |
format | Online Article Text |
id | pubmed-6664526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-66645262019-08-05 Risk factors for the formation of double-contour sign and tophi in gout Sun, Chao Qi, Xuan Tian, Yu Gao, Lixia Jin, Hongtao Guo, Huifang J Orthop Surg Res Research Article BACKGROUND: This study aimed to confirm the diagnostic accuracy of ultrasound (US) on gout and explore the potential risk factors for double-contour sign and tophi formation in gout patients. METHODS: The US analyses were performed on all knee, ankle, and first metatarsophalangeal (MTP 1) joints to reveal the type and location of lesions. While a questionnaire and blood biochemical index were used to explore the potential risk factors for double-contour sign and tophi in gout, the SPSS17.0 software was used for statistical analysis in the present study. RESULTS: Totally, 117 gout patients with 702 joints (38 lesions in knee joint, 93 lesions in ankle joint, and 112 lesions in MTP 1 joint) were enrolled in current analyses. Double-contour sign and joint effusion were the two most outstanding lesion manifestations in knee joints and ankle joints. Tophi and double-contour sign were the two most outstanding lesion manifestations in TMP 1 joints. Moreover, factors including uric acid (UA) level and the highest blood UA were potential risk factors of the double-contour sign, while age and history of US were potential risk factors for tophi. CONCLUSION: US was effective on the joints of gout patients. There was US sensitivity for tophi and double-contour sign in MTP 1 joints. The double-contour sign was a potential specific manifestation in knee joints and ankle joints. Furthermore, UA and highest blood UA level were potential risk factors for double-contour sign, while age and US history were potential risk factors for tophi. BioMed Central 2019-07-29 /pmc/articles/PMC6664526/ /pubmed/31358044 http://dx.doi.org/10.1186/s13018-019-1280-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Sun, Chao Qi, Xuan Tian, Yu Gao, Lixia Jin, Hongtao Guo, Huifang Risk factors for the formation of double-contour sign and tophi in gout |
title | Risk factors for the formation of double-contour sign and tophi in gout |
title_full | Risk factors for the formation of double-contour sign and tophi in gout |
title_fullStr | Risk factors for the formation of double-contour sign and tophi in gout |
title_full_unstemmed | Risk factors for the formation of double-contour sign and tophi in gout |
title_short | Risk factors for the formation of double-contour sign and tophi in gout |
title_sort | risk factors for the formation of double-contour sign and tophi in gout |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664526/ https://www.ncbi.nlm.nih.gov/pubmed/31358044 http://dx.doi.org/10.1186/s13018-019-1280-0 |
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