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Optimization of Ultrasound-Assisted Extraction of Total Flavonoids from Dendranthema indicum var. aromaticum by Response Surface Methodology

Dendranthema indicum var. aromaticum is a new species with strong fragrance and is used as a herbal medicine by Chinese folks. The abundant flavonoids play important roles in its pharmacological activities. In this study, an ultrasound-assisted method was used to extract total flavonoids (TF) from D...

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Autores principales: Zhong, Lijie, Liu, Yi, Xiong, Bin, Chen, Lin, Zhang, Yaohua, Li, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664694/
https://www.ncbi.nlm.nih.gov/pubmed/31396433
http://dx.doi.org/10.1155/2019/1648782
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author Zhong, Lijie
Liu, Yi
Xiong, Bin
Chen, Lin
Zhang, Yaohua
Li, Chao
author_facet Zhong, Lijie
Liu, Yi
Xiong, Bin
Chen, Lin
Zhang, Yaohua
Li, Chao
author_sort Zhong, Lijie
collection PubMed
description Dendranthema indicum var. aromaticum is a new species with strong fragrance and is used as a herbal medicine by Chinese folks. The abundant flavonoids play important roles in its pharmacological activities. In this study, an ultrasound-assisted method was used to extract total flavonoids (TF) from D. indicum var. aromaticum by response surface methodology. A quadratic model was developed to optimize the extraction conditions, whose accuracy was verified by statistic analysis. Ethanol and acetic acid at the volume ratio of 70% : 2% were selected as the extract solvent. The optimized extraction conditions were as follows: extraction time, 40 min; solid/liquid ratio, 1 : 23 g/mL; and temperature, 60°C. This is the first report of an efficient and easy-operating method for TF extraction from D. indicum var. aromaticum. Besides, this study provides reference for future pharmacological research on D. indicum var. aromaticum and extraction of bioactive components from other herbs.
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spelling pubmed-66646942019-08-08 Optimization of Ultrasound-Assisted Extraction of Total Flavonoids from Dendranthema indicum var. aromaticum by Response Surface Methodology Zhong, Lijie Liu, Yi Xiong, Bin Chen, Lin Zhang, Yaohua Li, Chao J Anal Methods Chem Research Article Dendranthema indicum var. aromaticum is a new species with strong fragrance and is used as a herbal medicine by Chinese folks. The abundant flavonoids play important roles in its pharmacological activities. In this study, an ultrasound-assisted method was used to extract total flavonoids (TF) from D. indicum var. aromaticum by response surface methodology. A quadratic model was developed to optimize the extraction conditions, whose accuracy was verified by statistic analysis. Ethanol and acetic acid at the volume ratio of 70% : 2% were selected as the extract solvent. The optimized extraction conditions were as follows: extraction time, 40 min; solid/liquid ratio, 1 : 23 g/mL; and temperature, 60°C. This is the first report of an efficient and easy-operating method for TF extraction from D. indicum var. aromaticum. Besides, this study provides reference for future pharmacological research on D. indicum var. aromaticum and extraction of bioactive components from other herbs. Hindawi 2019-07-17 /pmc/articles/PMC6664694/ /pubmed/31396433 http://dx.doi.org/10.1155/2019/1648782 Text en Copyright © 2019 Lijie Zhong et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhong, Lijie
Liu, Yi
Xiong, Bin
Chen, Lin
Zhang, Yaohua
Li, Chao
Optimization of Ultrasound-Assisted Extraction of Total Flavonoids from Dendranthema indicum var. aromaticum by Response Surface Methodology
title Optimization of Ultrasound-Assisted Extraction of Total Flavonoids from Dendranthema indicum var. aromaticum by Response Surface Methodology
title_full Optimization of Ultrasound-Assisted Extraction of Total Flavonoids from Dendranthema indicum var. aromaticum by Response Surface Methodology
title_fullStr Optimization of Ultrasound-Assisted Extraction of Total Flavonoids from Dendranthema indicum var. aromaticum by Response Surface Methodology
title_full_unstemmed Optimization of Ultrasound-Assisted Extraction of Total Flavonoids from Dendranthema indicum var. aromaticum by Response Surface Methodology
title_short Optimization of Ultrasound-Assisted Extraction of Total Flavonoids from Dendranthema indicum var. aromaticum by Response Surface Methodology
title_sort optimization of ultrasound-assisted extraction of total flavonoids from dendranthema indicum var. aromaticum by response surface methodology
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664694/
https://www.ncbi.nlm.nih.gov/pubmed/31396433
http://dx.doi.org/10.1155/2019/1648782
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