Mechanistic interpretation of non-coding variants for discovering transcriptional regulators of drug response

BACKGROUND: Identification of functional non-coding variants and their mechanistic interpretation is a major challenge of modern genomics, especially for precision medicine. Transcription factor (TF) binding profiles and epigenomic landscapes in reference samples allow functional annotation of the g...

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Detalles Bibliográficos
Autores principales: Xie, Xiaoman, Hanson, Casey, Sinha, Saurabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664756/
https://www.ncbi.nlm.nih.gov/pubmed/31362726
http://dx.doi.org/10.1186/s12915-019-0679-8

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