A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases

BACKGROUND: Genomic medicine has paved the way for identifying biomarkers and therapeutically actionable targets for complex diseases, but is complicated by the involvement of thousands of variably expressed genes across multiple cell types. Single-cell RNA-sequencing study (scRNA-seq) allows the ch...

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Detalles Bibliográficos
Autores principales: Gawel, Danuta R., Serra-Musach, Jordi, Lilja, Sandra, Aagesen, Jesper, Arenas, Alex, Asking, Bengt, Bengnér, Malin, Björkander, Janne, Biggs, Sophie, Ernerudh, Jan, Hjortswang, Henrik, Karlsson, Jan-Erik, Köpsen, Mattias, Lee, Eun Jung, Lentini, Antonio, Li, Xinxiu, Magnusson, Mattias, Martínez-Enguita, David, Matussek, Andreas, Nestor, Colm E., Schäfer, Samuel, Seifert, Oliver, Sonmez, Ceylan, Stjernman, Henrik, Tjärnberg, Andreas, Wu, Simon, Åkesson, Karin, Shalek, Alex K., Stenmarker, Margaretha, Zhang, Huan, Gustafsson, Mika, Benson, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664760/
https://www.ncbi.nlm.nih.gov/pubmed/31358043
http://dx.doi.org/10.1186/s13073-019-0657-3

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