Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection

BACKGROUND: Familial hypercholesterolemia type IIA (FH) is due to mutations in the low-density lipoprotein receptor (LDLR) resulting in elevated levels of low-density lipoprotein cholesterol (LDL-c) in plasma and in premature cardiovascular diseases. As hepatocytes are the only cells capable of meta...

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Detalles Bibliográficos
Autores principales: Caron, Jérôme, Pène, Véronique, Tolosa, Laia, Villaret, Maxime, Luce, Eléanor, Fourrier, Angélique, Heslan, Jean-Marie, Saheb, Samir, Bruckert, Eric, Gómez-Lechón, María José, Nguyen, Tuan Huy, Rosenberg, Arielle R., Weber, Anne, Dubart-Kupperschmitt, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664765/
https://www.ncbi.nlm.nih.gov/pubmed/31358055
http://dx.doi.org/10.1186/s13287-019-1342-6

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