Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability

BACKGROUND: Mesenchymal stem cells (MSCs) are attracting increasing interest for cell-based therapies, making use of both their immuno-modulating and regenerative potential. For such therapeutic applications, a massive in vitro expansion of donor cells is usually necessary to furnish sufficient mate...

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Detalles Bibliográficos
Autores principales: Hladik, Daniela, Höfig, Ines, Oestreicher, Ursula, Beckers, Johannes, Matjanovski, Martina, Bao, Xuanwen, Scherthan, Harry, Atkinson, Michael J., Rosemann, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664790/
https://www.ncbi.nlm.nih.gov/pubmed/31358047
http://dx.doi.org/10.1186/s13287-019-1334-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664790/
https://www.ncbi.nlm.nih.gov/pubmed/31358047
http://dx.doi.org/10.1186/s13287-019-1334-6

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