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Three Synchronous Primary Extranodal Mantle Cell Lymphomas Involving Torus Tubarius, Posterior Nasopharynx, and Base of the Tongue 65 Years After Treatment of Chronic Sinusitis with Nasopharyngeal Radium Irradiation
Patient: Male, 81 Final Diagnosis: Mantle cell lymphoma Symptoms: Dificulty in swallowing and pain in the right ear Medication: — Clinical Procedure: Otorhinolaryngology panendoscopy • biopsy of the tumors Specialty: Otolaryngology OBJECTIVE: Rare disease BACKGROUND: Radiation, specifically ionizing...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664868/ https://www.ncbi.nlm.nih.gov/pubmed/31326974 http://dx.doi.org/10.12659/AJCR.915742 |
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author | Plata, Andrew M. Pollard, Robert E. Fang, Yan Khalid, Ahmed Estalilla, Oscar C. Jelic, Tomislav M. |
author_facet | Plata, Andrew M. Pollard, Robert E. Fang, Yan Khalid, Ahmed Estalilla, Oscar C. Jelic, Tomislav M. |
author_sort | Plata, Andrew M. |
collection | PubMed |
description | Patient: Male, 81 Final Diagnosis: Mantle cell lymphoma Symptoms: Dificulty in swallowing and pain in the right ear Medication: — Clinical Procedure: Otorhinolaryngology panendoscopy • biopsy of the tumors Specialty: Otolaryngology OBJECTIVE: Rare disease BACKGROUND: Radiation, specifically ionizing radiation, causes broad-spectrum gene damage, including double-strand DNA breaks, single DNA strand breaks, cross links, and individual base lesions, thus causing chromosomal translocations, deletions, point mutations, and, consequently, various types of cancer. Radiation also causes genomic instability in cells, which enhances the rate of mutations in the descendants of the irradiated cell after many generations of normal replications. CASE REPORT: We report the first case of mantle cell lymphoma of the torus tubarius, and the first CD10-positive mantle cell lymphoma of the Waldeyer’s ring. Mantle cell lymphoma appeared 65 years after treatment of chronic sinusitis with nasopharyngeal radium irradiation. CONCLUSIONS: On the basis of the medical literature about atomic bomb survivors, nuclear plant workers, and radiologists exposed to radiation, and our case, we conclude that radiation can, in a very small percentage of exposed individuals, cause non-Hodgkin lymphoma: in 0.24% of atomic bomb survivors and in at least 0.13% of the patients treated with nasopharyngeal radium irradiation. Non-Hodgkin lymphoma can occur many decades after radiation exposure, and individuals treated with nasopharyngeal radium irradiation, usually in their childhood, need continuing follow-up. |
format | Online Article Text |
id | pubmed-6664868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66648682019-08-16 Three Synchronous Primary Extranodal Mantle Cell Lymphomas Involving Torus Tubarius, Posterior Nasopharynx, and Base of the Tongue 65 Years After Treatment of Chronic Sinusitis with Nasopharyngeal Radium Irradiation Plata, Andrew M. Pollard, Robert E. Fang, Yan Khalid, Ahmed Estalilla, Oscar C. Jelic, Tomislav M. Am J Case Rep Articles Patient: Male, 81 Final Diagnosis: Mantle cell lymphoma Symptoms: Dificulty in swallowing and pain in the right ear Medication: — Clinical Procedure: Otorhinolaryngology panendoscopy • biopsy of the tumors Specialty: Otolaryngology OBJECTIVE: Rare disease BACKGROUND: Radiation, specifically ionizing radiation, causes broad-spectrum gene damage, including double-strand DNA breaks, single DNA strand breaks, cross links, and individual base lesions, thus causing chromosomal translocations, deletions, point mutations, and, consequently, various types of cancer. Radiation also causes genomic instability in cells, which enhances the rate of mutations in the descendants of the irradiated cell after many generations of normal replications. CASE REPORT: We report the first case of mantle cell lymphoma of the torus tubarius, and the first CD10-positive mantle cell lymphoma of the Waldeyer’s ring. Mantle cell lymphoma appeared 65 years after treatment of chronic sinusitis with nasopharyngeal radium irradiation. CONCLUSIONS: On the basis of the medical literature about atomic bomb survivors, nuclear plant workers, and radiologists exposed to radiation, and our case, we conclude that radiation can, in a very small percentage of exposed individuals, cause non-Hodgkin lymphoma: in 0.24% of atomic bomb survivors and in at least 0.13% of the patients treated with nasopharyngeal radium irradiation. Non-Hodgkin lymphoma can occur many decades after radiation exposure, and individuals treated with nasopharyngeal radium irradiation, usually in their childhood, need continuing follow-up. International Scientific Literature, Inc. 2019-07-21 /pmc/articles/PMC6664868/ /pubmed/31326974 http://dx.doi.org/10.12659/AJCR.915742 Text en © Am J Case Rep, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles Plata, Andrew M. Pollard, Robert E. Fang, Yan Khalid, Ahmed Estalilla, Oscar C. Jelic, Tomislav M. Three Synchronous Primary Extranodal Mantle Cell Lymphomas Involving Torus Tubarius, Posterior Nasopharynx, and Base of the Tongue 65 Years After Treatment of Chronic Sinusitis with Nasopharyngeal Radium Irradiation |
title | Three Synchronous Primary Extranodal Mantle Cell Lymphomas Involving Torus Tubarius, Posterior Nasopharynx, and Base of the Tongue 65 Years After Treatment of Chronic Sinusitis with Nasopharyngeal Radium Irradiation |
title_full | Three Synchronous Primary Extranodal Mantle Cell Lymphomas Involving Torus Tubarius, Posterior Nasopharynx, and Base of the Tongue 65 Years After Treatment of Chronic Sinusitis with Nasopharyngeal Radium Irradiation |
title_fullStr | Three Synchronous Primary Extranodal Mantle Cell Lymphomas Involving Torus Tubarius, Posterior Nasopharynx, and Base of the Tongue 65 Years After Treatment of Chronic Sinusitis with Nasopharyngeal Radium Irradiation |
title_full_unstemmed | Three Synchronous Primary Extranodal Mantle Cell Lymphomas Involving Torus Tubarius, Posterior Nasopharynx, and Base of the Tongue 65 Years After Treatment of Chronic Sinusitis with Nasopharyngeal Radium Irradiation |
title_short | Three Synchronous Primary Extranodal Mantle Cell Lymphomas Involving Torus Tubarius, Posterior Nasopharynx, and Base of the Tongue 65 Years After Treatment of Chronic Sinusitis with Nasopharyngeal Radium Irradiation |
title_sort | three synchronous primary extranodal mantle cell lymphomas involving torus tubarius, posterior nasopharynx, and base of the tongue 65 years after treatment of chronic sinusitis with nasopharyngeal radium irradiation |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664868/ https://www.ncbi.nlm.nih.gov/pubmed/31326974 http://dx.doi.org/10.12659/AJCR.915742 |
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