Cargando…

BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation

BACKGROUND: Breast cancer is the neoplasm with both the highest incidence and mortality rate among women worldwide. Given the known snake venom cytotoxicity towards several tumor types, we evaluated the effects of BthTX-I from Bothrops jararacussu on MCF7, SKBR3, and MDAMB231 breast cancer cell line...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bezerra, Patrícia Heloise Alves, Ferreira, Isadora Marques, Franceschi, Beatriz Tinoco, Bianchini, Francine, Ambrósio, Luciana, Cintra, Adélia Cristina O., Sampaio, Suely Vilela, de Castro, Fabíola Attié, Torqueti, Maria Regina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Centro de Estudos de Venenos e Animais Peçonhentos 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665320/ https://www.ncbi.nlm.nih.gov/pubmed/31384244 http://dx.doi.org/10.1590/1678-9199-JVATITD-2019-0010

Ejemplares similares

Linear B-cell epitopes in BthTX-I, BthTX-II and BthA-I, phospholipase A(2's )from Bothrops jararacussu snake venom, recognized by therapeutically neutralizing commercial horse antivenom
por: De-Simone, Salvatore, et al.
Publicado: (2014)

Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines
por: Prinholato da Silva, Cássio, et al.
Publicado: (2015)

A New Approach to Inhibiting Triple-Negative Breast Cancer: In Vitro, Ex Vivo and In Vivo Antiangiogenic Effect of BthTx-II, a PLA(2)-Asp-49 from Bothrops jararacussu Venom
por: Van Petten de Vasconcelos Azevedo, Fernanda, et al.
Publicado: (2022)

Antibacterial Activity of the Non-Cytotoxic Peptide (p-BthTX-I)(2) and Its Serum Degradation Product against Multidrug-Resistant Bacteria
por: Santos-Filho, Norival A., et al.
Publicado: (2017)

Effects of Dimerization, Dendrimerization, and Chirality in p-BthTX-I Peptide Analogs on the Antibacterial Activity and Enzymatic Inhibition of the SARS-CoV-2 PL(pro) Protein
por: Bitencourt, Natália Vitória, et al.
Publicado: (2023)

Heparin at low concentration acts as antivenom against Bothrops jararacussu venom and bothropstoxin-I neurotoxic and myotoxic actions
por: Rostelato-Ferreira, Sandro, et al.
Publicado: (2010)

Can anti-bothropstoxin-I antibodies discriminate between Bothrops jararaca and Bothrops jararacussu venoms?
por: Araujo, Ricardo Teixeira, et al.
Publicado: (2017)

Inhibition of Bothrops jararacussu venom activities by Plathymenia reticulata Benth extracts
por: Farrapo, Nicole M, et al.
Publicado: (2011)

Cytotoxic and pro-apoptotic action of MjTX-I, a phospholipase A2 isolated from Bothrops moojeni snake venom, towards leukemic cells
por: Benati, Rogério Bodini, et al.
Publicado: (2018)

The Triterpenoid Betulin Protects against the Neuromuscular Effects of Bothrops jararacussu Snake Venom In Vivo
por: Ferraz, Miriéle Cristina, et al.
Publicado: (2015)

A C-Type Lectin from Bothrops jararacussu Venom Disrupts Staphylococcal Biofilms
por: Klein, Raphael Contelli, et al.
Publicado: (2015)

Pulsed ultrasound therapy accelerates the recovery of skeletal muscle damage induced by Bothrops jararacussu venom
por: Saturnino-Oliveira, J., et al.
Publicado: (2012)

Chemical Constituents of the Bark of Dipteryx alata Vogel, an Active Species against Bothrops jararacussu Venom
por: Puebla, Pilar, et al.
Publicado: (2010)

Size Matters: An Evaluation of the Molecular Basis of Ontogenetic Modifications in the Composition of Bothrops jararacussu Snake Venom
por: Freitas-de-Sousa, Luciana A., et al.
Publicado: (2020)

An Isoflavone from Dipteryx alata Vogel is Active against the in Vitro Neuromuscular Paralysis of Bothrops jararacussu Snake Venom and Bothropstoxin I, and Prevents Venom-Induced Myonecrosis
por: Ferraz, Miriéle C., et al.
Publicado: (2014)

Refolding by High Pressure of a Toxin Containing Seven Disulfide Bonds: Bothropstoxin-1 from Bothrops jararacussu
por: Balduino, Keli N., et al.
Publicado: (2010)

Vellozia flavicans Mart. ex Schult. hydroalcoholic extract inhibits the neuromuscular blockade induced by Bothrops jararacussu venom
por: Tribuiani, Natália, et al.
Publicado: (2014)

Bothrops moojeni L-amino acid oxidase induces apoptosis and epigenetic modulation on Bcr-Abl(+) cells
por: Burin, Sandra Mara, et al.
Publicado: (2020)

Human neutrophil migration and activation by BJcuL, a galactose binding lectin purified from Bothrops jararacussu venom
por: Elifio-Esposito, Selene, et al.
Publicado: (2011)

Anti-ophidian activity of Bredemeyera floribunda Willd. (Polygalaceae) root extract on the local effects induced by Bothrops jararacussu venom
por: Alves, N.T.Q., et al.
Publicado: (2018)

Cordia salicifolia and Lafoensia pacari plant extracts against the local effects of Bothrops jararacussu and Philodryas olfersii snake venoms
por: Schezaro-Ramos, Raphael, et al.
Publicado: (2020)

Inhibition of the Myotoxicity Induced by Bothrops jararacussu Venom and Isolated Phospholipases A(2) by Specific Camelid Single-Domain Antibody Fragments
por: Prado, Nidiane D. R., et al.
Publicado: (2016)

The allosteric activation mechanism of a phospholipase A(2)-like toxin from Bothrops jararacussu venom: a dynamic description
por: Gomes, Antoniel A. S., et al.
Publicado: (2020)

In Silico Evaluation of Quercetin Methylated Derivatives on the Interaction with Secretory Phospholipases A2 from Crotalus durissus terrificus and Bothrops jararacussu
por: Belchor, Mariana Novo, et al.
Publicado: (2023)

Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A(2) from Bothrops atrox snake venom
por: Menaldo, Danilo L., et al.
Publicado: (2015)

Alkylation of Histidine Residues of Bothrops jararacussu Venom Proteins and Isolated Phospholipases A(2): A Biotechnological Tool to Improve the Production of Antibodies
por: Guimarães, C. L. S., et al.
Publicado: (2014)

Light Emitting Diode Photobiomodulation Enhances Oxidative Redox Capacity in Murine Macrophages Stimulated with Bothrops jararacussu Venom and Isolated PLA(2)s
por: dos Reis, Valdison Pereira, et al.
Publicado: (2022)

Presynaptic Proteins as Markers of the Neurotoxic Activity of BmjeTX-I and BmjeTX-II Toxins from Bothrops marajoensis (Marajó Lancehead) Snake Venom
por: Lisboa, Antonio, et al.
Publicado: (2016)

Neutrophils activated by BJcuL, a C-type lectin isolated from Bothrops jararacussu venom, decrease the invasion potential of neuroblastoma SK-N-SH cells in vitro
por: Carneiro-Goetten, Jessica Ohana Lemes, et al.
Publicado: (2020)

Unmasking Snake Venom of Bothrops leucurus: Purification and Pharmacological and Structural Characterization of New PLA(2) Bleu TX-III
por: Marangoni, Fábio André, et al.
Publicado: (2013)

Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways
por: Ayres, Lorena Rocha, et al.
Publicado: (2015)

Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism
por: Salvador, Guilherme H. M., et al.
Publicado: (2018)

Proteopeptidomic, Functional and Immunoreactivity Characterization of Bothrops moojeni Snake Venom: Influence of Snake Gender on Venom Composition
por: Amorim, Fernanda Gobbi, et al.
Publicado: (2018)

Antitumor effect of Bothrops jararaca venom.
por: da Silva, Reinaldo J, et al.
Publicado: (2002)

Subpopulations of mononuclear leukocytes associated with inhibition of Ehrlich ascites tumor growth by treatment with Bothrops jararaca venom.
por: de Vieira Santos, Mariana Morena, et al.
Publicado: (2004)

Harpalycin 2 inhibits the enzymatic and platelet aggregation activities of PrTX-III, a D49 phospholipase A(2) from Bothrops pirajai venom
por: Ximenes, Rafael M, et al.
Publicado: (2012)

Biochemical Characterization and Pharmacological Properties of New Basic PLA(2) BrTX-I Isolated from Bothrops roedingeri (Roedinger's Lancehead) Mertens, 1942, Snake Venom
por: Gomes Heleno, Mauricio Aurelio, et al.
Publicado: (2013)

Enzymatic and Pro-Inflammatory Activities of Bothrops lanceolatus Venom: Relevance for Envenomation
por: Delafontaine, Marie, et al.
Publicado: (2017)

What’s in a Name? Michael N. Marsh, BTh, DPhil, DM, DSc, FRCP
por: Ensari, Arzu
Publicado: (2021)

The prevalence of disability and associated factors among community adults in the baseline of CHCN-BTH Cohort Study
por: Zhu, Hui-Ping, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tvalmcvgtr1511e0bkbf1jvdc7