Discovery and preclinical characterization of [(18)F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

PURPOSE: Tau deposition is a key pathological feature of Alzheimer’s disease (AD) and other neurodegenerative disorders. The spreading of tau neurofibrillary tangles across defined brain regions corresponds to the observed level of cognitive decline in AD. Positron-emission tomography (PET) has prov...

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Detalles Bibliográficos
Autores principales: Kroth, Heiko, Oden, Felix, Molette, Jerome, Schieferstein, Hanno, Capotosti, Francesca, Mueller, Andre, Berndt, Mathias, Schmitt-Willich, Heribert, Darmency, Vincent, Gabellieri, Emanuele, Boudou, Cédric, Juergens, Tanja, Varisco, Yvan, Vokali, Efthymia, Hickman, David T., Tamagnan, Gilles, Pfeifer, Andrea, Dinkelborg, Ludger, Muhs, Andreas, Stephens, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667408/
https://www.ncbi.nlm.nih.gov/pubmed/31264169
http://dx.doi.org/10.1007/s00259-019-04397-2

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