Cargando…

ER stress abrogates the immunosuppressive effect of IL-10 on human macrophages through inhibition of STAT3 activation

OBJECTIVE AND DESIGN: To determine whether ER stress affects the inhibitory pathways of the human immune system, particularly the immunosuppressive effect of IL-10 on macrophages. MATERIAL OR SUBJECTS: In vitro stimulation of human monocyte-derived macrophages. TREATMENT: Cells were stimulated with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hansen, Ivo S., Schoonejans, Josca M., Sritharan, Lathees, van Burgsteden, Johan A., Ambarus, Carmen A., Baeten, Dominique L. P., den Dunnen, Jeroen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2019
Materias:	Original Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667425/ https://www.ncbi.nlm.nih.gov/pubmed/31227842 http://dx.doi.org/10.1007/s00011-019-01261-9

Ejemplares similares

C-Reactive Protein Controls IL-23 Production by Human Monocytes
por: Geyer, Chiara E., et al.
Publicado: (2021)

FcγR-TLR Cross-Talk Enhances TNF Production by Human Monocyte-Derived DCs via IRF5-Dependent Gene Transcription and Glycolytic Reprogramming
por: Hoepel, Willianne, et al.
Publicado: (2019)

The inflammatory function of human IgA
por: Hansen, Ivo S., et al.
Publicado: (2018)

Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis
por: Ambarus, Carmen A, et al.
Publicado: (2012)

Immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10
por: Ambarus, Carmen, et al.
Publicado: (2011)

Altered cytokine expression by macrophages from HLA-B27-positive spondyloarthritis patients without evidence of endoplasmic reticulum stress
por: Ambarus, Carmen A, et al.
Publicado: (2018)

STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice
por: Bitsch, Rebekka, et al.
Publicado: (2022)

Dysregulated Fcγ receptor IIa‐induced cytokine production in dendritic cells of lupus nephritis patients
por: Newling, M., et al.
Publicado: (2019)

Soluble Immune Complexes Shift the TLR-Induced Cytokine Production of Distinct Polarized Human Macrophage Subsets towards IL-10
por: Ambarus, Carmen A., et al.
Publicado: (2012)

Control of Cytokine Production by Human Fc Gamma Receptors: Implications for Pathogen Defense and Autoimmunity
por: Vogelpoel, Lisa T. C., et al.
Publicado: (2015)

FcαRI co-stimulation converts human intestinal CD103(+) dendritic cells into pro-inflammatory cells through glycolytic reprogramming
por: Hansen, Ivo S., et al.
Publicado: (2018)

Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner
por: Schoonejans, Josca M., et al.
Publicado: (2021)

Immunosuppression abrogates resistance of young rabbits to Rabbit Haemorrhagic Disease (RHD)
por: Marques, Raquel M, et al.
Publicado: (2014)

Fc gamma receptor IIa suppresses type I and III interferon production by human myeloid immune cells
por: Newling, Melissa, et al.
Publicado: (2018)

Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1
por: Morozov, Vladimir A, et al.
Publicado: (2012)

OX40 ligand expression abrogates the immunosuppressive function of retinal pigment epithelium
por: Cunningham, Matthew A, et al.
Publicado: (2013)

Optimizing NK Cell-Based Immunotherapy in Myeloid Leukemia: Abrogating an Immunosuppressive Microenvironment
por: Kaweme, Natasha Mupeta, et al.
Publicado: (2021)

Targeted TLR9-activation/STAT3-blocking abrogates immunosuppressive functions of myeloid-derived suppressor cells from late-stage prostate cancer patients
por: Md Sakib Hossain, Dewan, et al.
Publicado: (2014)

Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages
por: Vogelpoel, Lisa T. C., et al.
Publicado: (2014)

IL-33/ST2-mediated inflammation in macrophages is directly abrogated by IL-10 during rheumatoid arthritis
por: Chen, Si, et al.
Publicado: (2017)

Sodium cantharidate targets STAT3 and abrogates EGFR inhibitor resistance in osteosarcoma
por: Ji, Xiang Lu, et al.
Publicado: (2019)

Identification of distinct polarized macrophage subsets in inflammatory arthritis
por: Ambarus, C, et al.
Publicado: (2010)

Abrogating endocrine resistance by targeting ERα and PI3K in breast cancer
por: Fox, Emily M., et al.
Publicado: (2012)

Selective inhibition of protein secretion by abrogating receptor–coat interactions during ER export
por: Gomez-Navarro, Natalia, et al.
Publicado: (2022)

IL-17 in spondyloarthritis: is the T-party over?
por: Yeremenko, Nataliya, et al.
Publicado: (2011)

Tumor NLRP3-Derived IL-1β Drives the IL-6/STAT3 Axis Resulting in Sustained MDSC-Mediated Immunosuppression
por: Tengesdal, Isak W., et al.
Publicado: (2021)

miR-221/222 sponge abrogates tamoxifen resistance in ER-positive breast cancer cells through restoring the expression of ERα
por: Ouyang, Yan Xiu, et al.
Publicado: (2021)

Dalpiciclib partially abrogates ER signaling activation induced by pyrotinib in HER2(+)HR(+) breast cancer
por: Bu, Jiawen, et al.
Publicado: (2023)

IL-23 Inhibition in Ankylosing Spondylitis: Where Did It Go Wrong?
por: Baeten, Dominique, et al.
Publicado: (2021)

Targeting S1PR1/STAT3 loop abrogates desmoplasia and chemosensitizes pancreatic cancer to gemcitabine
por: Lankadasari, Manendra Babu, et al.
Publicado: (2018)

Tie2 Signaling Cooperates with TNF to Promote the Pro-Inflammatory Activation of Human Macrophages Independently of Macrophage Functional Phenotype
por: García, Samuel, et al.
Publicado: (2014)

Tunicamycin-Induced ER Stress is Accompanied with Oxidative Stress via Abrogation of Sulfur Amino Acids Metabolism in the Liver
por: Kim, Sou Hyun, et al.
Publicado: (2018)

Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERβ and IL-6/gp130/STAT3 signaling
por: Pozios, Ioannis, et al.
Publicado: (2020)

Sex-specific effects of maternal metformin intervention during glucose-intolerant obese pregnancy on body composition and metabolic health in aged mouse offspring
por: Schoonejans, Josca M., et al.
Publicado: (2022)

Abrogation of Bronchial Eosinophilic Inflammation and Airway Hyperreactivity in Signal Transducers and Activators of Transcription (STAT)6-deficient Mice
por: Akimoto, Toshihiko, et al.
Publicado: (1998)

JAK Kinase Inhibition Abrogates STAT3 Activation and Head and Neck Squamous Cell Carcinoma Tumor Growth()()
por: Sen, Malabika, et al.
Publicado: (2015)

NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway
por: Wang, Huailin, et al.
Publicado: (2021)

Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling
por: Cole, Suzanne, et al.
Publicado: (2020)

Neutralization of IL-15 abrogates experimental immune-mediated cholangitis in diet-induced obese mice
por: Reyes, José L., et al.
Publicado: (2018)

Caspase-1 Abrogates the Salutary Effects of Hypertrophic Preconditioning in Pressure Overload Hearts via IL-1β and IL-18
por: Dai, Fangjie, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5vm1n72mrpu87v9n6mcoksg0va