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Epidemic threshold in pairwise models for clustered networks: closures and fast correlations

The epidemic threshold is probably the most studied quantity in the modelling of epidemics on networks. For a large class of networks and dynamics, it is well studied and understood. However, it is less so for clustered networks where theoretical results are mostly limited to idealised networks. In...

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Autores principales: Barnard, Rosanna C., Berthouze, Luc, Simon, Péter L., Kiss, István Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667428/
https://www.ncbi.nlm.nih.gov/pubmed/31079178
http://dx.doi.org/10.1007/s00285-019-01380-1
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author Barnard, Rosanna C.
Berthouze, Luc
Simon, Péter L.
Kiss, István Z.
author_facet Barnard, Rosanna C.
Berthouze, Luc
Simon, Péter L.
Kiss, István Z.
author_sort Barnard, Rosanna C.
collection PubMed
description The epidemic threshold is probably the most studied quantity in the modelling of epidemics on networks. For a large class of networks and dynamics, it is well studied and understood. However, it is less so for clustered networks where theoretical results are mostly limited to idealised networks. In this paper we focus on a class of models known as pairwise models where, to our knowledge, no analytical result for the epidemic threshold exists. We show that by exploiting the presence of fast variables and using some standard techniques from perturbation theory we are able to obtain the epidemic threshold analytically. We validate this new threshold by comparing it to the threshold based on the numerical solution of the full system. The agreement is found to be excellent over a wide range of values of the clustering coefficient, transmission rate and average degree of the network. Interestingly, we find that the analytical form of the threshold depends on the choice of closure, highlighting the importance of model selection when dealing with real-world epidemics. Nevertheless, we expect that our method will extend to other systems in which fast variables are present.
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spelling pubmed-66674282019-08-14 Epidemic threshold in pairwise models for clustered networks: closures and fast correlations Barnard, Rosanna C. Berthouze, Luc Simon, Péter L. Kiss, István Z. J Math Biol Article The epidemic threshold is probably the most studied quantity in the modelling of epidemics on networks. For a large class of networks and dynamics, it is well studied and understood. However, it is less so for clustered networks where theoretical results are mostly limited to idealised networks. In this paper we focus on a class of models known as pairwise models where, to our knowledge, no analytical result for the epidemic threshold exists. We show that by exploiting the presence of fast variables and using some standard techniques from perturbation theory we are able to obtain the epidemic threshold analytically. We validate this new threshold by comparing it to the threshold based on the numerical solution of the full system. The agreement is found to be excellent over a wide range of values of the clustering coefficient, transmission rate and average degree of the network. Interestingly, we find that the analytical form of the threshold depends on the choice of closure, highlighting the importance of model selection when dealing with real-world epidemics. Nevertheless, we expect that our method will extend to other systems in which fast variables are present. Springer Berlin Heidelberg 2019-05-11 2019 /pmc/articles/PMC6667428/ /pubmed/31079178 http://dx.doi.org/10.1007/s00285-019-01380-1 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Barnard, Rosanna C.
Berthouze, Luc
Simon, Péter L.
Kiss, István Z.
Epidemic threshold in pairwise models for clustered networks: closures and fast correlations
title Epidemic threshold in pairwise models for clustered networks: closures and fast correlations
title_full Epidemic threshold in pairwise models for clustered networks: closures and fast correlations
title_fullStr Epidemic threshold in pairwise models for clustered networks: closures and fast correlations
title_full_unstemmed Epidemic threshold in pairwise models for clustered networks: closures and fast correlations
title_short Epidemic threshold in pairwise models for clustered networks: closures and fast correlations
title_sort epidemic threshold in pairwise models for clustered networks: closures and fast correlations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667428/
https://www.ncbi.nlm.nih.gov/pubmed/31079178
http://dx.doi.org/10.1007/s00285-019-01380-1
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