A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides

We describe pLink 2, a search engine with higher speed and reliability for proteome-scale identification of cross-linked peptides. With a two-stage open search strategy facilitated by fragment indexing, pLink 2 is ~40 times faster than pLink 1 and 3~10 times faster than Kojak. Furthermore, using sim...

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Detalles Bibliográficos
Autores principales: Chen, Zhen-Lin, Meng, Jia-Ming, Cao, Yong, Yin, Ji-Li, Fang, Run-Qian, Fan, Sheng-Bo, Liu, Chao, Zeng, Wen-Feng, Ding, Yue-He, Tan, Dan, Wu, Long, Zhou, Wen-Jing, Chi, Hao, Sun, Rui-Xiang, Dong, Meng-Qiu, He, Si-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667459/
https://www.ncbi.nlm.nih.gov/pubmed/31363125
http://dx.doi.org/10.1038/s41467-019-11337-z

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