Cargando…

A principled strategy for mapping enhancers to genes

Mapping enhancers to genes is a fundamental goal of modern biology. We have developed an innovative strategy that maps enhancers to genes in a principled manner. We illustrate its power by applying it to Myrf. Despite being a master regulator of oligodendrocytes, oligodendrocyte enhancers governing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Dongkyeong, An, Hongjoo, Shearer, Randall S., Sharif, Mohamed, Fan, Chuandong, Choi, Jin-ok, Ryu, Sun, Park, Yungki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667464/ https://www.ncbi.nlm.nih.gov/pubmed/31363138 http://dx.doi.org/10.1038/s41598-019-47521-w

Ejemplares similares

Elucidating the transactivation domain of the pleiotropic transcription factor Myrf
por: Choi, Jin-ok, et al.
Publicado: (2018)

Uncovering oligodendrocyte enhancers that control Cnp expression
por: Fan, Chuandong, et al.
Publicado: (2023)

Identifying an oligodendrocyte enhancer that regulates Olig2 expression
por: Fan, Chuandong, et al.
Publicado: (2022)

Functional mechanisms of MYRF DNA-binding domain mutations implicated in birth defects
por: Fan, Chuandong, et al.
Publicado: (2021)

Homo-trimerization is essential for the transcription factor function of Myrf for oligodendrocyte differentiation
por: Kim, Dongkyeong, et al.
Publicado: (2017)

Functional mechanism and pathogenic potential of MYRF ICA domain mutations implicated in birth defects
por: An, Hongjoo, et al.
Publicado: (2020)

Molecular mechanism for the multiple sclerosis risk variant rs17594362
por: Kim, Dongkyeong, et al.
Publicado: (2019)

Critical assessment of sequence-based protein-protein interaction prediction methods that do not require homologous protein sequences
por: Park, Yungki
Publicado: (2009)

Principles of Electroanatomic Mapping
por: Bhakta, Deepak, et al.
Publicado: (2008)

A flaw in the typical evaluation scheme for pair-input computational predictions
por: Park, Yungki, et al.
Publicado: (2012)

PRC2 Acts as a Critical Timer That Drives Oligodendrocyte Fate over Astrocyte Identity by Repressing the Notch Pathway
por: Wang, Wenxian, et al.
Publicado: (2020)

Quantification of the Diversity in Gene Structures Using the Principles of Polarization Mapping
por: Zimnyakov, Dmitry, et al.
Publicado: (2023)

Prediction of the burial status of transmembrane residues of helical membrane proteins
por: Park, Yungki, et al.
Publicado: (2007)

Smartphone-based indoor map construction: principles and applications
por: Gao, Ruipeng, et al.
Publicado: (2018)

Transverse thoracic muscle plane block as a routine strategy for cardiac enhanced recovery after surgery in sternotomy: A retrospective analysis
por: Deng, Qiweixi, et al.
Publicado: (2022)

A Bacteriophage Tailspike Domain Promotes Self-Cleavage of a Human Membrane-Bound Transcription Factor, the Myelin Regulatory Factor MYRF
por: Li, Zhihua, et al.
Publicado: (2013)

Principles of RNA processing from analysis of enhanced CLIP maps for 150 RNA binding proteins
por: Van Nostrand, Eric L., et al.
Publicado: (2020)

Strategies for the multiplex mapping of genes to traits
por: Garst, Andrew, et al.
Publicado: (2013)

Applying Business Strategy Principles to Radiology: Weight/Variance Principle
por: Gyftopoulos, Soterios, et al.
Publicado: (2020)

PRINCIPLES UNDERLYING SENSORY MAP TOPOGRAPHY IN PRIMARY VISUAL CORTEX
por: Kremkow, Jens, et al.
Publicado: (2016)

Dirichlet’s principle, conformal mapping, and minimal surfaces
por: Courant, Richard
Publicado: (1977)

Exosomes/microvesicles target SARS-CoV-2 via innate and RNA-induced immunity with PIWI-piRNA system
por: Ikhlas, Shoeb, et al.
Publicado: (2021)

GWAS, QTL mapping and gene expression analyses in Brassica napus reveal genetic control of branching morphogenesis
por: He, Yajun, et al.
Publicado: (2017)

Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells
por: Alkasalias, Twana, et al.
Publicado: (2022)

Global fashion retailers’ responses to external and internal crises during the COVID-19 pandemic
por: Kim, Sanghee, et al.
Publicado: (2021)

Convolutional neural network-based reconstruction for positronium annihilation localization
por: Jegal, Jin, et al.
Publicado: (2022)

Developmental and architectural principles of the lateral-line neural map
por: Pujol-Martí, Jesús, et al.
Publicado: (2013)

Correction: Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells
por: Alkasalias, Twana, et al.
Publicado: (2022)

Principles of enhanced heat transfer
por: Webb, Ralph L
Publicado: (1994)

Visual Maps Development: Reconsidering the Role of Retinal Efnas and Basic Principle of Map Alignment
por: Savier, Elise, et al.
Publicado: (2018)

General Principles of Antimicrobial Therapy
por: Leekha, Surbhi, et al.
Publicado: (2011)

Combinatorial transient gene expression strategies to enhance terpenoid production in plants
por: Park, Soyoung, et al.
Publicado: (2022)

Systematic mapping and modeling of 3D enhancer-promoter interactions in early mouse embryonic lineages reveal regulatory principles that determine the levels and cell-type specificity of gene expression
por: Murphy, Dylan, et al.
Publicado: (2023)

Therapeutic siRNA: Principles, Challenges, and Strategies
por: Gavrilov, Kseniya, et al.
Publicado: (2012)

Principles and Framework for eHealth Strategy Development
por: Scott, Richard E, et al.
Publicado: (2013)

Determination of growth-coupling strategies and their underlying principles
por: Alter, Tobias B., et al.
Publicado: (2019)

PROTAC: targeted drug strategy. Principles and limitations
por: Koroleva, O. A., et al.
Publicado: (2022)

Stein manifolds and holomorphic mappings: the homotopy principle in complex analysis
por: Forstnerič, Franc
Publicado: (2017)

Fixed point theory and best approximation the KKM-map principle
por: Singh, Sankatha, et al.
Publicado: (1997)

Broca's Region: Novel Organizational Principles and Multiple Receptor Mapping
por: Amunts, Katrin, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_20rjetsjdk560g1dj40b8kgpa3