m(6)A modification of a 3′ UTR site reduces RME1 mRNA levels to promote meiosis

Despite the vast number of modification sites mapped within mRNAs, known examples of consequential mRNA modifications remain rare. Here, we provide multiple lines of evidence to show that Ime4p, an N6-methyladenosine (m(6)A) methyltransferase required for meiosis in yeast, acts by methylating a site...

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Detalles Bibliográficos
Autores principales: Bushkin, G. Guy, Pincus, David, Morgan, Jeffrey T., Richardson, Kris, Lewis, Caroline, Chan, Sze Ham, Bartel, David P., Fink, Gerald R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667471/
https://www.ncbi.nlm.nih.gov/pubmed/31363087
http://dx.doi.org/10.1038/s41467-019-11232-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667471/
https://www.ncbi.nlm.nih.gov/pubmed/31363087
http://dx.doi.org/10.1038/s41467-019-11232-7

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