Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant

Precise editing of genomic DNA can be achieved upon repair of CRISPR-induced DNA double-stranded breaks (DSBs) by homology-directed repair (HDR). However, the efficiency of this process is limited by DSB repair pathways competing with HDR, such as non-homologous end joining (NHEJ). Here we individua...

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Detalles Bibliográficos
Autores principales: Nambiar, Tarun S., Billon, Pierre, Diedenhofen, Giacomo, Hayward, Samuel B., Taglialatela, Angelo, Cai, Kunheng, Huang, Jen-Wei, Leuzzi, Giuseppe, Cuella-Martin, Raquel, Palacios, Andrew, Gupta, Anuj, Egli, Dieter, Ciccia, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667477/
https://www.ncbi.nlm.nih.gov/pubmed/31363085
http://dx.doi.org/10.1038/s41467-019-11105-z

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