Profiling host ANP32A splicing landscapes to predict influenza A virus polymerase adaptation

Species’ differences in cellular factors limit avian influenza A virus (IAV) zoonoses and human pandemics. The IAV polymerase, vPol, harbors evolutionary sites to overcome restriction and determines virulence. Here, we establish host ANP32A as a critical driver of selection, and identify host-specif...

Descripción completa

Detalles Bibliográficos
Autores principales: Domingues, Patricia, Eletto, Davide, Magnus, Carsten, Turkington, Hannah L., Schmutz, Stefan, Zagordi, Osvaldo, Lenk, Matthias, Beer, Martin, Stertz, Silke, Hale, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667478/
https://www.ncbi.nlm.nih.gov/pubmed/31363119
http://dx.doi.org/10.1038/s41467-019-11388-2

Ejemplares similares

Ejemplares similares