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Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats

Arterial hypertension is a cardiovascular disease that leads to important systemic alterations and drastically impairs normal organ function over time. Hypertension affects around 700 million men of reproductive age and hypertensive men present increased risk for reproductive disorders, such as erec...

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Autores principales: Colli, Lucas Giglio, Belardin, Larissa Berloffa, Echem, Cinthya, Akamine, Eliana Hiromi, Antoniassi, Mariana Pereira, Andretta, Rhayza Roberta, Mathias, Lucas Solla, Rodrigues, Stephen Fernandes de Paula, Bertolla, Ricardo Pimenta, de Carvalho, Maria Helena Catelli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667492/
https://www.ncbi.nlm.nih.gov/pubmed/31363128
http://dx.doi.org/10.1038/s41598-019-47157-w
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author Colli, Lucas Giglio
Belardin, Larissa Berloffa
Echem, Cinthya
Akamine, Eliana Hiromi
Antoniassi, Mariana Pereira
Andretta, Rhayza Roberta
Mathias, Lucas Solla
Rodrigues, Stephen Fernandes de Paula
Bertolla, Ricardo Pimenta
de Carvalho, Maria Helena Catelli
author_facet Colli, Lucas Giglio
Belardin, Larissa Berloffa
Echem, Cinthya
Akamine, Eliana Hiromi
Antoniassi, Mariana Pereira
Andretta, Rhayza Roberta
Mathias, Lucas Solla
Rodrigues, Stephen Fernandes de Paula
Bertolla, Ricardo Pimenta
de Carvalho, Maria Helena Catelli
author_sort Colli, Lucas Giglio
collection PubMed
description Arterial hypertension is a cardiovascular disease that leads to important systemic alterations and drastically impairs normal organ function over time. Hypertension affects around 700 million men of reproductive age and hypertensive men present increased risk for reproductive disorders, such as erectile dysfunction. However, the link between arterial hypertension and male reproductive disorders is associative at best. Moreover, many studies have reported associations between decreased male fertility and/or semen quality and alterations to general male health. In this study we aim to investigate the effect of systemic high blood pressure in sperm quality, sperm functional characteristics and testicular physiology in a rat model. Hypertensive rats presented altered testicular morphology – mainly vascular alterations and impaired testicular vasomotion. Hypertensive rats also presented decrease in sperm concentration, DNA integrity and increased percentages of sperm with dysfunctional mitochondria, intracellular superoxide anion activity and abnormal morphology. This study provides mechanistic insights by which arterial hypertension affects the testes, evidencing the testes as another target organ for hypertension as well as its impact on sperm quality.
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spelling pubmed-66674922019-08-06 Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats Colli, Lucas Giglio Belardin, Larissa Berloffa Echem, Cinthya Akamine, Eliana Hiromi Antoniassi, Mariana Pereira Andretta, Rhayza Roberta Mathias, Lucas Solla Rodrigues, Stephen Fernandes de Paula Bertolla, Ricardo Pimenta de Carvalho, Maria Helena Catelli Sci Rep Article Arterial hypertension is a cardiovascular disease that leads to important systemic alterations and drastically impairs normal organ function over time. Hypertension affects around 700 million men of reproductive age and hypertensive men present increased risk for reproductive disorders, such as erectile dysfunction. However, the link between arterial hypertension and male reproductive disorders is associative at best. Moreover, many studies have reported associations between decreased male fertility and/or semen quality and alterations to general male health. In this study we aim to investigate the effect of systemic high blood pressure in sperm quality, sperm functional characteristics and testicular physiology in a rat model. Hypertensive rats presented altered testicular morphology – mainly vascular alterations and impaired testicular vasomotion. Hypertensive rats also presented decrease in sperm concentration, DNA integrity and increased percentages of sperm with dysfunctional mitochondria, intracellular superoxide anion activity and abnormal morphology. This study provides mechanistic insights by which arterial hypertension affects the testes, evidencing the testes as another target organ for hypertension as well as its impact on sperm quality. Nature Publishing Group UK 2019-07-30 /pmc/articles/PMC6667492/ /pubmed/31363128 http://dx.doi.org/10.1038/s41598-019-47157-w Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Colli, Lucas Giglio
Belardin, Larissa Berloffa
Echem, Cinthya
Akamine, Eliana Hiromi
Antoniassi, Mariana Pereira
Andretta, Rhayza Roberta
Mathias, Lucas Solla
Rodrigues, Stephen Fernandes de Paula
Bertolla, Ricardo Pimenta
de Carvalho, Maria Helena Catelli
Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats
title Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats
title_full Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats
title_fullStr Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats
title_full_unstemmed Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats
title_short Systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats
title_sort systemic arterial hypertension leads to decreased semen quality and alterations in the testicular microcirculation in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667492/
https://www.ncbi.nlm.nih.gov/pubmed/31363128
http://dx.doi.org/10.1038/s41598-019-47157-w
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