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One-Step Synthesis of Nitrogen-Doped Hydrophilic Mesoporous Carbons from Chitosan-Based Triconstituent System for Drug Release
In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs-x/3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) we...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667578/ https://www.ncbi.nlm.nih.gov/pubmed/31363913 http://dx.doi.org/10.1186/s11671-019-3075-y |
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author | Wang, Xianshu Pan, Hongyan Lin, Qian Wu, Hong Jia, Shuangzhu Shi, Yongyong |
author_facet | Wang, Xianshu Pan, Hongyan Lin, Qian Wu, Hong Jia, Shuangzhu Shi, Yongyong |
author_sort | Wang, Xianshu |
collection | PubMed |
description | In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs-x/3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) were used as template agents, and biocompatible chitosan (CS) was used as the carbon source and nitrogen source. These carbon materials were characterized by TG, BET, XRD, Raman, FTIR, TEM, XPS, and contact angle measuring device. The adsorption and release properties of mesoporous carbon materials for the poorly soluble antitumor drug hydroxycamptothecin (HCPT) were investigated. Results showed that nanospherical mesoporous carbon materials were successfully prepared with high specific surface area (2061.6 m(2)/g), narrowly pore size distribution (2.01–3.65 nm), and high nitrogen content (4.75–6.04%). Those NMCs-x showed a satisfactory hydrophilicity, which gradually increased with the increasing of surface N content. And the better hydrophilicity of NMCs-x was, the larger adsorption capacity for HCPT. The absorption capacity of NMCs-x towards HCPT was in the following orders: q(NMCs-5/3) > q(NMCs-6/3) > q(NMCs-7/3) > q(NMCs-8/3). NMCs-5/3 had the largest saturated adsorption capacity of HCPT (1013.51 mg g(−1)) and higher dissolution rate (93.75%). |
format | Online Article Text |
id | pubmed-6667578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-66675782019-08-14 One-Step Synthesis of Nitrogen-Doped Hydrophilic Mesoporous Carbons from Chitosan-Based Triconstituent System for Drug Release Wang, Xianshu Pan, Hongyan Lin, Qian Wu, Hong Jia, Shuangzhu Shi, Yongyong Nanoscale Res Lett Nano Express In situ nitrogen-doped hydrophilic mesoporous carbon spheres with different carbon-to-silicon (C/Si) ratios (NMCs-x/3, x = 5, 6, 7, and 8) were prepared by one-step method coupled with a spray drying and carbonizing technique, in which triblock copolymer (F127) and tetraethyl orthosilicate (TEOS) were used as template agents, and biocompatible chitosan (CS) was used as the carbon source and nitrogen source. These carbon materials were characterized by TG, BET, XRD, Raman, FTIR, TEM, XPS, and contact angle measuring device. The adsorption and release properties of mesoporous carbon materials for the poorly soluble antitumor drug hydroxycamptothecin (HCPT) were investigated. Results showed that nanospherical mesoporous carbon materials were successfully prepared with high specific surface area (2061.6 m(2)/g), narrowly pore size distribution (2.01–3.65 nm), and high nitrogen content (4.75–6.04%). Those NMCs-x showed a satisfactory hydrophilicity, which gradually increased with the increasing of surface N content. And the better hydrophilicity of NMCs-x was, the larger adsorption capacity for HCPT. The absorption capacity of NMCs-x towards HCPT was in the following orders: q(NMCs-5/3) > q(NMCs-6/3) > q(NMCs-7/3) > q(NMCs-8/3). NMCs-5/3 had the largest saturated adsorption capacity of HCPT (1013.51 mg g(−1)) and higher dissolution rate (93.75%). Springer US 2019-07-30 /pmc/articles/PMC6667578/ /pubmed/31363913 http://dx.doi.org/10.1186/s11671-019-3075-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Nano Express Wang, Xianshu Pan, Hongyan Lin, Qian Wu, Hong Jia, Shuangzhu Shi, Yongyong One-Step Synthesis of Nitrogen-Doped Hydrophilic Mesoporous Carbons from Chitosan-Based Triconstituent System for Drug Release |
title | One-Step Synthesis of Nitrogen-Doped Hydrophilic Mesoporous Carbons from Chitosan-Based Triconstituent System for Drug Release |
title_full | One-Step Synthesis of Nitrogen-Doped Hydrophilic Mesoporous Carbons from Chitosan-Based Triconstituent System for Drug Release |
title_fullStr | One-Step Synthesis of Nitrogen-Doped Hydrophilic Mesoporous Carbons from Chitosan-Based Triconstituent System for Drug Release |
title_full_unstemmed | One-Step Synthesis of Nitrogen-Doped Hydrophilic Mesoporous Carbons from Chitosan-Based Triconstituent System for Drug Release |
title_short | One-Step Synthesis of Nitrogen-Doped Hydrophilic Mesoporous Carbons from Chitosan-Based Triconstituent System for Drug Release |
title_sort | one-step synthesis of nitrogen-doped hydrophilic mesoporous carbons from chitosan-based triconstituent system for drug release |
topic | Nano Express |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667578/ https://www.ncbi.nlm.nih.gov/pubmed/31363913 http://dx.doi.org/10.1186/s11671-019-3075-y |
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