When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling

The diagnosis of central nervous system (CNS) infection relies upon analysis of cerebrospinal fluid (CSF). We present 4 cases of CNS infections associated with basal meningitis and hydrocephalus with normal ventricular CSF but grossly abnormal lumbar CSF. We discuss CSF ventricular–lumbar compositio...

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Autores principales: Khan, Sadid F, Macauley, Thornton, Tong, Steven Y C, Xie, Ouli, Hughes, Carly, Hall, Nicholas D P, Mahanty, Siddhartha, Jennens, Ian, Street, Alan C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
ID Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667712/
https://www.ncbi.nlm.nih.gov/pubmed/31363769
http://dx.doi.org/10.1093/ofid/ofz324
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author Khan, Sadid F
Macauley, Thornton
Tong, Steven Y C
Xie, Ouli
Hughes, Carly
Hall, Nicholas D P
Mahanty, Siddhartha
Jennens, Ian
Street, Alan C
author_facet Khan, Sadid F
Macauley, Thornton
Tong, Steven Y C
Xie, Ouli
Hughes, Carly
Hall, Nicholas D P
Mahanty, Siddhartha
Jennens, Ian
Street, Alan C
author_sort Khan, Sadid F
collection PubMed
description The diagnosis of central nervous system (CNS) infection relies upon analysis of cerebrospinal fluid (CSF). We present 4 cases of CNS infections associated with basal meningitis and hydrocephalus with normal ventricular CSF but grossly abnormal lumbar CSF. We discuss CSF ventricular–lumbar composition gradients and putative pathophysiological mechanisms and highlight clinical clues for clinicians.
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spelling pubmed-66677122019-08-05 When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling Khan, Sadid F Macauley, Thornton Tong, Steven Y C Xie, Ouli Hughes, Carly Hall, Nicholas D P Mahanty, Siddhartha Jennens, Ian Street, Alan C Open Forum Infect Dis ID Case The diagnosis of central nervous system (CNS) infection relies upon analysis of cerebrospinal fluid (CSF). We present 4 cases of CNS infections associated with basal meningitis and hydrocephalus with normal ventricular CSF but grossly abnormal lumbar CSF. We discuss CSF ventricular–lumbar composition gradients and putative pathophysiological mechanisms and highlight clinical clues for clinicians. Oxford University Press 2019-07-08 /pmc/articles/PMC6667712/ /pubmed/31363769 http://dx.doi.org/10.1093/ofid/ofz324 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle ID Case
Khan, Sadid F
Macauley, Thornton
Tong, Steven Y C
Xie, Ouli
Hughes, Carly
Hall, Nicholas D P
Mahanty, Siddhartha
Jennens, Ian
Street, Alan C
When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling
title When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling
title_full When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling
title_fullStr When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling
title_full_unstemmed When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling
title_short When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling
title_sort when ventricular cerebrospinal fluid assessment misleads: basal meningitis and the importance of lumbar puncture sampling
topic ID Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667712/
https://www.ncbi.nlm.nih.gov/pubmed/31363769
http://dx.doi.org/10.1093/ofid/ofz324
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