An Integrated Approach to Aggregate Control for Therapeutic Bispecific Antibodies Using an Improved Three Column Mab Platform‐Like Purification Process

Single chain variable fragment‐IgGs (scFv‐IgG) are a class of bispecific antibodies consisting of two single chain variable fragments (scFv) that are fused to an intact IgG molecule. A common trend observed for expression of scFv‐IgGs in mammalian cell culture is a higher level of aggregates (10%–30...

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Detalles Bibliográficos
Autores principales: Andrade, Cassia, Arnold, Lindsay, Motabar, Dana, Aspelund, Matthew, Tang, Alison, Hunter, Alan, Chung, Wai Keen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667909/
https://www.ncbi.nlm.nih.gov/pubmed/30298991
http://dx.doi.org/10.1002/btpr.2720

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