Cargando…

Safety, Pharmacokinetics, and Immunogenicity of Obiltoxaximab After Intramuscular Administration to Healthy Humans

Inhalational anthrax is a highly lethal infection caused by Bacillus anthracis and a serious bioterrorism threat. Protective antigen (PA) is a critical component required for the virulence of Bacillus anthracis. Obiltoxaximab, a high‐affinity monoclonal antibody that neutralizes PA, is approved in t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nagy, Christa F., Leach, Timothy S., King, Alex, Guttendorf, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668011/ https://www.ncbi.nlm.nih.gov/pubmed/29125719 http://dx.doi.org/10.1002/cpdd.410

Ejemplares similares

Animal‐to‐Human Dose Translation of Obiltoxaximab for Treatment of Inhalational Anthrax Under the US FDA Animal Rule
por: Nagy, CF, et al.
Publicado: (2016)

Pharmacokinetics of levosulpiride after single and multiple intramuscular administrations in healthy Chinese volunteers
por: Gong, Chuting, et al.
Publicado: (2014)

The pharmacokinetics of buserelin after intramuscular administration in pigs and cows
por: Kong, Jingyuan, et al.
Publicado: (2022)

Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep
por: Diez, Raquel, et al.
Publicado: (2022)

Efficacy Projection of Obiltoxaximab for Treatment of Inhalational Anthrax across a Range of Disease Severity
por: Yamamoto, Brent J., et al.
Publicado: (2016)

Pharmacokinetic behavior of 16-dehydropregnenolone after intramuscular administration in rats
por: Yang, Hong-Ying, et al.
Publicado: (2011)

Pharmacokinetics of Tildipirosin in Ewes after Intravenous, Intramuscular and Subcutaneous Administration
por: Galecio, Juan Sebastián, et al.
Publicado: (2020)

Comparison of pharmacokinetics and safety between CE-fosphenytoin sodium, fosphenytoin sodium, and phenytoin sodium after intravenous and intramuscular administration in healthy volunteers
por: Li, Xiaojiao, et al.
Publicado: (2023)

Pharmacokinetics of meloxicam in pigeons after single intravenous, oral, and intramuscular administration
por: Chen, Jun-Cheng, et al.
Publicado: (2023)

Pharmacokinetics of flunixin meglumine in mature swine after intravenous, intramuscular and oral administration
por: Pairis-Garcia, Monique D, et al.
Publicado: (2013)

Pharmacokinetics of marbofloxacin after intravenous and intramuscular administration in Hanwoo, Korean native cattle
por: BELEW, Sileshi, et al.
Publicado: (2014)

Donepezil and Rivastigmine: Pharmacokinetic Profile and Brain-targeting After Intramuscular Administration in Rats
por: Karasova, Jana Zdarova, et al.
Publicado: (2020)

Pharmacokinetics and Pharmacodynamic Effects of Flunixin after Intravenous, Intramuscular and Oral Administration to Dairy Goats
por: Königsson, K, et al.
Publicado: (2003)

Pharmacokinetic profiles of levofloxacin after intravenous, intramuscular and subcutaneous administration to rabbits (Oryctolagus cuniculus)
por: Sitovs, Andrejs, et al.
Publicado: (2020)

Comparison of Piroxicam Pharmacokinetics and Anti-Inflammatory Effect in Rats after Intra-Articular and Intramuscular Administration
por: Park, Chan Woong, et al.
Publicado: (2014)

Oxytetracycline Pharmacokinetics After Intramuscular Administration in Cows with Clinical Metritis Associated with Trueperella Pyogenes Infection
por: Mileva, Rositsa, et al.
Publicado: (2020)

Pharmacokinetics, pharmacodynamics, safety, and immunogenicity of Pelmeg(®), a pegfilgrastim biosimilar in healthy subjects
por: Roth, Karsten, et al.
Publicado: (2019)

Obiltoxaximab Prevents Disseminated Bacillus anthracis Infection and Improves Survival during Pre- and Postexposure Prophylaxis in Animal Models of Inhalational Anthrax
por: Yamamoto, Brent J., et al.
Publicado: (2016)

Physiologically based modelling of tranexamic acid pharmacokinetics following intravenous, intramuscular, sub-cutaneous and oral administration in healthy volunteers
por: Kane, Zoe, et al.
Publicado: (2021)

Pharmacokinetics of butorphanol following intravenous and intramuscular administration in donkeys: A preliminary study
por: Ebner, Lisa, et al.
Publicado: (2022)

Pharmacokinetics and pharmacodynamics of intranasal and intramuscular administration of naloxone in working dogs administered fentanyl
por: Barr, Ciara A., et al.
Publicado: (2023)

Pharmacokinetics of intramuscular alfaxalone and its echocardiographic, cardiopulmonary and sedative effects in healthy dogs
por: Cruz-Benedetti, Inga-Catalina, et al.
Publicado: (2018)

The pharmacokinetics of Hemiscorpius lepturus scorpion venom and Razi antivenom following intramuscular administration in rat
por: Jalali, Amir, et al.
Publicado: (2012)

Pharmacokinetics of Intravenous, Intramuscular, Oral, and Transdermal Administration of Flunixin Meglumine in Pre-wean Piglets
por: Kittrell, Heather C., et al.
Publicado: (2020)

Safety studies and viral shedding of intramuscular administration of oncolytic vaccinia virus TG6002 in healthy beagle dogs
por: Béguin, Jérémy, et al.
Publicado: (2020)

Comparative immunogenicity analysis of intradermal versus intramuscular administration of SARS-CoV-2 RBD epitope peptide-based immunogen In vivo
por: Yadav, Naveen, et al.
Publicado: (2021)

Comparison of the pharmacokinetics, safety, and immunogenicity of MSB11022, a biosimilar of adalimumab, with Humira(®) in healthy subjects
por: Hyland, Elizabeth, et al.
Publicado: (2016)

Pharmacokinetics, Immunogenicity and Safety Study for SHR-1309 Injection and Perjeta® in Healthy Chinese Male Volunteers
por: Cui, Yingzi, et al.
Publicado: (2021)

Immunogenicity and safety of intramuscular versus subcutaneous administration of a combined measles, mumps, rubella, and varicella vaccine to children 12 to 18 months of age
por: Haas, Hervé, et al.
Publicado: (2019)

Magnesium sulfate pharmacokinetics after intramuscular dosing in women with preeclampsia
por: Brookfield, Kathleen, et al.
Publicado: (2021)

Safety, pharmacokinetics, and pharmacodynamics of TV-1380, a novel mutated butyrylcholinesterase treatment for cocaine addiction, after single and multiple intramuscular injections in healthy subjects
por: Cohen-Barak, Orit, et al.
Publicado: (2015)

Comparative Pharmacokinetics of Cefquinome (Cobactan 2.5%) following Repeated Intramuscular Administrations in Sheep and Goats
por: El-Hewaity, Mohamed, et al.
Publicado: (2014)

Posaconazole Pharmacokinetics in Healthy Cats after Oral and Intravenous Administration
por: Mawby, D.I., et al.
Publicado: (2016)

Pharmacokinetics of isavuconazole in healthy cats after oral and intravenous administration
por: Woerde, Dennis J., et al.
Publicado: (2022)

Isolated Infraspinatus Myositis after Intramuscular Vaccine Administration
por: Samuelson, Eric R., et al.
Publicado: (2022)

Pharmacokinetic equivalence, comparable safety, and immunogenicity of an adalimumab biosimilar product (M923) to Humira in healthy subjects
por: Hillson, Jan, et al.
Publicado: (2018)

Pharmacokinetics, Pharmacodynamics, Safety and Immunogenicity of CMAB807, a New Denosumab Biosimilar, in Healthy Chinese Subjects
por: Chen, Hanjing, et al.
Publicado: (2022)

Corrigendum: Pharmacokinetics, Immunogenicity and Safety Study for SHR-1309 Injection and Perjeta(®) in Healthy Chinese Male Volunteers
por: Cui, Yingzi, et al.
Publicado: (2022)

Assessment of the effects of immunogenicity on the pharmacokinetics, efficacy and safety of tildrakizumab
por: Kimball, A.B., et al.
Publicado: (2019)

Pharmacokinetics and Immunogenicity of Frunevetmab in Osteoarthritic Cats Following Intravenous and Subcutaneous Administration
por: Walters, Rodney R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c431mv72n4n5t9vgl104on0at5