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Reduced alphabet of prebiotic amino acids optimally encodes the conformational space of diverse extant protein folds
BACKGROUND: There is wide agreement that only a subset of the twenty standard amino acids existed prebiotically in sufficient concentrations to form functional polypeptides. We ask how this subset, postulated as {A,D,E,G,I,L,P,S,T,V}, could have formed structures stable enough to found metabolic pat...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668081/ https://www.ncbi.nlm.nih.gov/pubmed/31362700 http://dx.doi.org/10.1186/s12862-019-1464-6 |