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Post-surgical inhibition of phosphatidylinositol 3-kinase attenuates the plantar incision-induced postoperative pain behavior via spinal Akt activation in male mice

BACKGROUND: Postoperative pain (POP) is a severe acute pain encountered in patients suffering from an operation, and is less than adequately controlled by the currently available analgesics. Phosphatidylinositol 3-kinase (PI3K) has been reported to have an important role in neuropathic and inflammat...

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Detalles Bibliográficos
Autores principales:	Xu, Bing, Mo, Cheng, Lv, Chengmei, Liu, Susu, Li, Jun, Chen, Jieying, Wei, Yanhong, An, Hongwei, Ma, Li, Guan, Xuehai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668088/ https://www.ncbi.nlm.nih.gov/pubmed/31366324 http://dx.doi.org/10.1186/s12868-019-0521-9

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