Naturally occurring mutations in PB1 affect influenza A virus replication fidelity, virulence, and adaptability

BACKGROUND: Mutations in the PB1 subunit of RNA-dependent RNA polymerase (RdRp) of influenza A virus can affect replication fidelity. Before the influenza A/H1N1 pandemic in 2009, most human influenza A/H1N1 viruses contained the avian-associated residue, serine, at position 216 in PB1. However, nea...

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Detalles Bibliográficos
Autores principales: Lin, Ruey-Wen, Chen, Guang-Wu, Sung, Hsiang-Hsuan, Lin, Ren-Jye, Yen, Li-Chen, Tseng, Yu-Ling, Chang, Yung-Kun, Lien, Shu-Pei, Shih, Shin-Ru, Liao, Ching-Len
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668090/
https://www.ncbi.nlm.nih.gov/pubmed/31366399
http://dx.doi.org/10.1186/s12929-019-0547-4

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