Cargando…

Combination therapy targeting both innate and adaptive immunity improves survival in a pre-clinical model of ovarian cancer

BACKGROUND: Despite major advancements in immunotherapy among a number of solid tumors, response rates among ovarian cancer patients remain modest. Standard treatment for ovarian cancer is still surgery followed by taxane- and platinum-based chemotherapy. Thus, there is an urgent need to develop nov...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hartl, Christina A., Bertschi, Adrian, Puerto, Regina Bou, Andresen, Carolin, Cheney, Emily M., Mittendorf, Elizabeth A., Guerriero, Jennifer L., Goldberg, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668091/ https://www.ncbi.nlm.nih.gov/pubmed/31362778 http://dx.doi.org/10.1186/s40425-019-0654-5

Ejemplares similares

Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity
por: von Roemeling, Christina A., et al.
Publicado: (2020)

Comparing syngeneic and autochthonous models of breast cancer to identify tumor immune components that correlate with response to immunotherapy in breast cancer
por: Lal, Jessica Castrillon, et al.
Publicado: (2021)

CRISPR-Mediated Editing of the B Cell Receptor in Primary Human B Cells
por: Greiner, Vera, et al.
Publicado: (2019)

Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients
por: Kniotek, Monika, et al.
Publicado: (2017)

Elucidating Specificity Opens a Window to the Complexity of Both the Innate and Adaptive Immune Systems
por: Belz, Gabrielle T.
Publicado: (2020)

T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
por: Schmid, Daniela, et al.
Publicado: (2017)

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome
por: Lessard, Christopher J., et al.
Publicado: (2013)

An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity
por: Eri, R D, et al.
Publicado: (2011)

Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study
por: Maalmi, Haifa, et al.
Publicado: (2021)

Innate immune control of influenza virus interspecies adaptation
por: Denz, Parker J., et al.
Publicado: (2023)

Cell-intrinsic adrenergic signaling controls the adaptive NK cell response to viral infection
por: Diaz-Salazar, Carlos, et al.
Publicado: (2020)

Immune Modulation by Schistosoma mansoni Antigens in NOD Mice: Effects on Both Innate and Adaptive Immune Systems
por: Zaccone, Paola, et al.
Publicado: (2010)

NF-κB Functions in Tumor Initiation by Suppressing the Surveillance of Both Innate and Adaptive Immune Cells
por: Wang, David J., et al.
Publicado: (2014)

Diabetes mellitus exacerbates experimental autoimmune myasthenia gravis via modulating both adaptive and innate immunity
por: Zhang, Peng, et al.
Publicado: (2021)

Resolution of viral load in mild COVID-19 patients is associated with both innate and adaptive immune responses
por: Anantharaj, Anbalagan, et al.
Publicado: (2022)

Implication of PMLIV in Both Intrinsic and Innate Immunity
por: El Asmi, Faten, et al.
Publicado: (2014)

Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
por: Minkah, Nana K., et al.
Publicado: (2019)

Innate and Adaptive Immune Responses Both Contribute to Pathological CD4 T Cell Activation in HIV-1 Infected Ugandans
por: Eller, Michael A., et al.
Publicado: (2011)

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems
por: Stinchcombe, Jane C, et al.
Publicado: (2011)

IL-18 Inhibits Growth of Murine Orthotopic Prostate Carcinomas via Both Adaptive and Innate Immune Mechanisms
por: Tse, Brian Wan-Chi, et al.
Publicado: (2011)

Prostate cancer stem cells are targets of both innate and adaptive immunity and elicit tumor-specific immune responses
por: Jachetti, Elena, et al.
Publicado: (2013)

The Micro-Immunotherapy Medicine 2LEID Exhibits an Immunostimulant Effect by Boosting Both Innate and Adaptive Immune Responses
por: Jacques, Camille, et al.
Publicado: (2021)

Correction to: Diabetes mellitus exacerbates experimental autoimmune myasthenia gravis via modulating both adaptive and innate immunity
por: Zhang, Peng, et al.
Publicado: (2021)

Non-cytotoxic nanoparticles re-educating macrophages achieving both innate and adaptive immune responses for tumor therapy
por: Wang, Shengmei, et al.
Publicado: (2022)

Trypanosoma cruzi-Derived Molecules Induce Anti-Tumour Protection by Favouring Both Innate and Adaptive Immune Responses
por: Freire, Teresa, et al.
Publicado: (2022)

Innate-like T cells straddle innate and adaptive immunity by revising antigen-receptor responsiveness
por: Wencker, Melanie, et al.
Publicado: (2013)

Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity
por: Canedo-Marroquín, Gisela, et al.
Publicado: (2017)

Innate and Adaptive Immune Interactions at the Fetal–Maternal Interface in Healthy Human Pregnancy and Pre-Eclampsia
por: Hsu, Peter, et al.
Publicado: (2014)

Next-Generation Sequencing Identifies Deregulation of MicroRNAs Involved in Both Innate and Adaptive Immune Response in ALK+ ALCL
por: Steinhilber, Julia, et al.
Publicado: (2015)

SAG2A protein from Toxoplasma gondii interacts with both innate and adaptive immune compartments of infected hosts
por: Macêdo, Arlindo G, et al.
Publicado: (2013)

Thymopentin ameliorates dextran sulfate sodium-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes
por: Cao, Qiuhua, et al.
Publicado: (2019)

Neutrophils: Their Role in Innate and Adaptive Immunity
por: Rosales, Carlos, et al.
Publicado: (2016)

Innate-Adaptive Immune Crosstalk
por: Shanker, Anil, et al.
Publicado: (2015)

Innate and Adaptive Immunity to Mucorales
por: Ghuman, Harlene, et al.
Publicado: (2017)

Nuclear receptor LXRβ controls fitness and functionality of activated T cells
por: Michaels, Anthony J., et al.
Publicado: (2020)

Innate and adaptive immunity in human epilepsies
por: Bauer, Jan, et al.
Publicado: (2017)

Inflammation and Cell Death of the Innate and Adaptive Immune System during Sepsis
por: Nedeva, Christina
Publicado: (2021)

Exercise Cuts Both Ways with ROS in Remodifying Innate and Adaptive Responses: Rewiring the Redox Mechanism of the Immune System during Exercise
por: Thirupathi, Anand, et al.
Publicado: (2021)

Viral RNA N(6)-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus
por: Xue, Miaoge, et al.
Publicado: (2021)

Peanut triacylglycerols activate innate immunity both in insects and mammals
por: Li, Wenyuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tsd0l5vc2q0jo7iul2d7ilq6qp