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Functional consequences of enhanced expression of STIM1 and Orai1 in Huh-7 hepatocellular carcinoma tumor-initiating cells
BACKGROUND: The endoplasmic reticulum (ER) Ca(2+) sensor, stromal interaction molecule1 (STIM1) activates the plasma membrane (PM) channel Orai1 in order to mediate store-operated Ca(2+) entry (SOCE) in response to ER store depletion. Enhanced expression of STIM1 in cancer tissue has been associated...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668110/ https://www.ncbi.nlm.nih.gov/pubmed/31366337 http://dx.doi.org/10.1186/s12885-019-5947-z |