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WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer

BACKGROUND: Stabilization of RAS is a key event for the hyper-activation of Wnt/β-catenin signaling and activation of cancer stem cell (CSC) in colorectal cancer (CRC). WD Repeat protein 76 (WDR76) mediates the polyubiquitination-dependent degradation of RAS in hepatocellular carcinoma (HCC). We inv...

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Detalles Bibliográficos
Autores principales:	Ro, Eun Ji, Cho, Yong-Hee, Jeong, Woo-Jeong, Park, Jong-Chan, Min, Do Sik, Choi, Kang-Yell
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668196/ https://www.ncbi.nlm.nih.gov/pubmed/31362761 http://dx.doi.org/10.1186/s12964-019-0403-x

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