Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers

We report a simple surface functionalization of glutathione-capped gold nanoclusters by hydrophobic ion pairing with alkylamine followed by a complete phase transfer to various organic solvents with maintained colloidal stability and photoluminescence properties. The described surface hydrophobicati...

Descripción completa

Detalles Bibliográficos
Autores principales: Alkilany, Alaaldin M., Alsotari, Shrouq, Alkawareek, Mahmoud Y., Abulateefeh, Samer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668383/
https://www.ncbi.nlm.nih.gov/pubmed/31366896
http://dx.doi.org/10.1038/s41598-019-47543-4
_version_ 1783440203666423808
author Alkilany, Alaaldin M.
Alsotari, Shrouq
Alkawareek, Mahmoud Y.
Abulateefeh, Samer R.
author_facet Alkilany, Alaaldin M.
Alsotari, Shrouq
Alkawareek, Mahmoud Y.
Abulateefeh, Samer R.
author_sort Alkilany, Alaaldin M.
collection PubMed
description We report a simple surface functionalization of glutathione-capped gold nanoclusters by hydrophobic ion pairing with alkylamine followed by a complete phase transfer to various organic solvents with maintained colloidal stability and photoluminescence properties. The described surface hydrophobication enables efficient encapsulation of gold nanoclusters into PLGA nanocarriers allowing their visualization inside cultured cells using confocal fluorescent microscopy. The simplicity and efficiency of the described protocols should extend the biomedical applications of these metallic nanoclusters as a fluorescent platform to label hydrophobic polymeric nanocarriers beyond conventional organic dyes.
format Online
Article
Text
id pubmed-6668383
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-66683832019-08-06 Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers Alkilany, Alaaldin M. Alsotari, Shrouq Alkawareek, Mahmoud Y. Abulateefeh, Samer R. Sci Rep Article We report a simple surface functionalization of glutathione-capped gold nanoclusters by hydrophobic ion pairing with alkylamine followed by a complete phase transfer to various organic solvents with maintained colloidal stability and photoluminescence properties. The described surface hydrophobication enables efficient encapsulation of gold nanoclusters into PLGA nanocarriers allowing their visualization inside cultured cells using confocal fluorescent microscopy. The simplicity and efficiency of the described protocols should extend the biomedical applications of these metallic nanoclusters as a fluorescent platform to label hydrophobic polymeric nanocarriers beyond conventional organic dyes. Nature Publishing Group UK 2019-07-31 /pmc/articles/PMC6668383/ /pubmed/31366896 http://dx.doi.org/10.1038/s41598-019-47543-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Alkilany, Alaaldin M.
Alsotari, Shrouq
Alkawareek, Mahmoud Y.
Abulateefeh, Samer R.
Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
title Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
title_full Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
title_fullStr Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
title_full_unstemmed Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
title_short Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
title_sort facile hydrophobication of glutathione-protected gold nanoclusters and encapsulation into poly(lactide-co-glycolide) nanocarriers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668383/
https://www.ncbi.nlm.nih.gov/pubmed/31366896
http://dx.doi.org/10.1038/s41598-019-47543-4
work_keys_str_mv AT alkilanyalaaldinm facilehydrophobicationofglutathioneprotectedgoldnanoclustersandencapsulationintopolylactidecoglycolidenanocarriers
AT alsotarishrouq facilehydrophobicationofglutathioneprotectedgoldnanoclustersandencapsulationintopolylactidecoglycolidenanocarriers
AT alkawareekmahmoudy facilehydrophobicationofglutathioneprotectedgoldnanoclustersandencapsulationintopolylactidecoglycolidenanocarriers
AT abulateefehsamerr facilehydrophobicationofglutathioneprotectedgoldnanoclustersandencapsulationintopolylactidecoglycolidenanocarriers

Ejemplares similares