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Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice

Moderate intravascular hemolysis is a common condition in newborns. It is followed by the accumulation of bilirubin, which is a secondary product of the activity of heme oxygenase-1, an enzyme that catalyzes the breakdown of heme released from disrupted erythrocytes and taken up by hepatic macrophag...

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Autores principales: Bednarz, Aleksandra, Lipiński, Paweł, Starzyński, Rafał R., Tomczyk, Mateusz, Nowak, Witold, Mucha, Olga, Ogórek, Mateusz, Pierzchała, Olga, Jończy, Aneta, Staroń, Robert, Śmierzchalska, Julia, Rajfur, Zenon, Baster, Zbigniew, Józkowicz, Alicja, Lenartowicz, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668426/
https://www.ncbi.nlm.nih.gov/pubmed/31366967
http://dx.doi.org/10.1038/s41598-019-47414-y
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author Bednarz, Aleksandra
Lipiński, Paweł
Starzyński, Rafał R.
Tomczyk, Mateusz
Nowak, Witold
Mucha, Olga
Ogórek, Mateusz
Pierzchała, Olga
Jończy, Aneta
Staroń, Robert
Śmierzchalska, Julia
Rajfur, Zenon
Baster, Zbigniew
Józkowicz, Alicja
Lenartowicz, Małgorzata
author_facet Bednarz, Aleksandra
Lipiński, Paweł
Starzyński, Rafał R.
Tomczyk, Mateusz
Nowak, Witold
Mucha, Olga
Ogórek, Mateusz
Pierzchała, Olga
Jończy, Aneta
Staroń, Robert
Śmierzchalska, Julia
Rajfur, Zenon
Baster, Zbigniew
Józkowicz, Alicja
Lenartowicz, Małgorzata
author_sort Bednarz, Aleksandra
collection PubMed
description Moderate intravascular hemolysis is a common condition in newborns. It is followed by the accumulation of bilirubin, which is a secondary product of the activity of heme oxygenase-1, an enzyme that catalyzes the breakdown of heme released from disrupted erythrocytes and taken up by hepatic macrophages. Although these cells are a major site of enzymatic heme breakdown in adults, we show here that epithelial cells of proximal tubules in the kidneys perform the functions of both heme uptake and catabolism in mouse neonates. A time-course study examining mouse pups during the neonatal period showed a gradual recovery from hemolysis, and concomitant decreases in the expression of heme-related genes and non-heme iron transporters in the proximal tubules. By adjusting the expression of iron-handling proteins in response to the disappearance of hemolysis in mouse neonates, the kidneys may play a role in the detoxification of iron and contribute to its recirculation from the primary urine to the blood.
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spelling pubmed-66684262019-08-06 Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice Bednarz, Aleksandra Lipiński, Paweł Starzyński, Rafał R. Tomczyk, Mateusz Nowak, Witold Mucha, Olga Ogórek, Mateusz Pierzchała, Olga Jończy, Aneta Staroń, Robert Śmierzchalska, Julia Rajfur, Zenon Baster, Zbigniew Józkowicz, Alicja Lenartowicz, Małgorzata Sci Rep Article Moderate intravascular hemolysis is a common condition in newborns. It is followed by the accumulation of bilirubin, which is a secondary product of the activity of heme oxygenase-1, an enzyme that catalyzes the breakdown of heme released from disrupted erythrocytes and taken up by hepatic macrophages. Although these cells are a major site of enzymatic heme breakdown in adults, we show here that epithelial cells of proximal tubules in the kidneys perform the functions of both heme uptake and catabolism in mouse neonates. A time-course study examining mouse pups during the neonatal period showed a gradual recovery from hemolysis, and concomitant decreases in the expression of heme-related genes and non-heme iron transporters in the proximal tubules. By adjusting the expression of iron-handling proteins in response to the disappearance of hemolysis in mouse neonates, the kidneys may play a role in the detoxification of iron and contribute to its recirculation from the primary urine to the blood. Nature Publishing Group UK 2019-07-31 /pmc/articles/PMC6668426/ /pubmed/31366967 http://dx.doi.org/10.1038/s41598-019-47414-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Bednarz, Aleksandra
Lipiński, Paweł
Starzyński, Rafał R.
Tomczyk, Mateusz
Nowak, Witold
Mucha, Olga
Ogórek, Mateusz
Pierzchała, Olga
Jończy, Aneta
Staroń, Robert
Śmierzchalska, Julia
Rajfur, Zenon
Baster, Zbigniew
Józkowicz, Alicja
Lenartowicz, Małgorzata
Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice
title Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice
title_full Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice
title_fullStr Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice
title_full_unstemmed Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice
title_short Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice
title_sort role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668426/
https://www.ncbi.nlm.nih.gov/pubmed/31366967
http://dx.doi.org/10.1038/s41598-019-47414-y
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