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β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology

Exposure to the environmental toxin β-methylamino-L-alanine (BMAA) is linked to amyotrophic lateral sclerosis (ALS), but its disease-promoting mechanism remains unknown. We propose that incorporation of BMAA into the ALS-linked protein Cu,Zn superoxide dismutase (SOD1) upon translation promotes prot...

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Detalles Bibliográficos
Autores principales:	Proctor, Elizabeth A., Mowrey, David D., Dokholyan, Nikolay V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668853/ https://www.ncbi.nlm.nih.gov/pubmed/31323035 http://dx.doi.org/10.1371/journal.pcbi.1007225

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