CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion

CHILD syndrome (Congenital Hemidysplasia, Ichthyosiform erythroderma, Limb Defects) is a rare X-linked dominant disease. The authors report a 2-month-old patient presenting with typical features of CHILD syndrome that was treated with a topical solution containing cholesterol and lovastatin, with co...

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Detalles Bibliográficos
Autores principales: Sandoval, Karina Romero, Machado, Maria Cecília Rivitti, de Oliveira, Zilda Najjar Prado, Nico, Marcello Menta Simonsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668949/
https://www.ncbi.nlm.nih.gov/pubmed/31365666
http://dx.doi.org/10.1590/abd1806-4841.20198789
Descripción
Sumario:CHILD syndrome (Congenital Hemidysplasia, Ichthyosiform erythroderma, Limb Defects) is a rare X-linked dominant disease. The authors report a 2-month-old patient presenting with typical features of CHILD syndrome that was treated with a topical solution containing cholesterol and lovastatin, with complete clearance of her CHILD nevus. The changes in skin lipid metabolism that explain the CHILD ichthyosiform nevus and their correction through topical application of cholesterol and lovastatin are discussed.

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