CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion

CHILD syndrome (Congenital Hemidysplasia, Ichthyosiform erythroderma, Limb Defects) is a rare X-linked dominant disease. The authors report a 2-month-old patient presenting with typical features of CHILD syndrome that was treated with a topical solution containing cholesterol and lovastatin, with co...

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Detalles Bibliográficos
Autores principales: Sandoval, Karina Romero, Machado, Maria Cecília Rivitti, de Oliveira, Zilda Najjar Prado, Nico, Marcello Menta Simonsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668949/
https://www.ncbi.nlm.nih.gov/pubmed/31365666
http://dx.doi.org/10.1590/abd1806-4841.20198789
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author Sandoval, Karina Romero
Machado, Maria Cecília Rivitti
de Oliveira, Zilda Najjar Prado
Nico, Marcello Menta Simonsen
author_facet Sandoval, Karina Romero
Machado, Maria Cecília Rivitti
de Oliveira, Zilda Najjar Prado
Nico, Marcello Menta Simonsen
author_sort Sandoval, Karina Romero
collection PubMed
description CHILD syndrome (Congenital Hemidysplasia, Ichthyosiform erythroderma, Limb Defects) is a rare X-linked dominant disease. The authors report a 2-month-old patient presenting with typical features of CHILD syndrome that was treated with a topical solution containing cholesterol and lovastatin, with complete clearance of her CHILD nevus. The changes in skin lipid metabolism that explain the CHILD ichthyosiform nevus and their correction through topical application of cholesterol and lovastatin are discussed.
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spelling pubmed-66689492019-08-05 CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion Sandoval, Karina Romero Machado, Maria Cecília Rivitti de Oliveira, Zilda Najjar Prado Nico, Marcello Menta Simonsen An Bras Dermatol Case Report CHILD syndrome (Congenital Hemidysplasia, Ichthyosiform erythroderma, Limb Defects) is a rare X-linked dominant disease. The authors report a 2-month-old patient presenting with typical features of CHILD syndrome that was treated with a topical solution containing cholesterol and lovastatin, with complete clearance of her CHILD nevus. The changes in skin lipid metabolism that explain the CHILD ichthyosiform nevus and their correction through topical application of cholesterol and lovastatin are discussed. Sociedade Brasileira de Dermatologia 2019 /pmc/articles/PMC6668949/ /pubmed/31365666 http://dx.doi.org/10.1590/abd1806-4841.20198789 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way.
spellingShingle Case Report
Sandoval, Karina Romero
Machado, Maria Cecília Rivitti
de Oliveira, Zilda Najjar Prado
Nico, Marcello Menta Simonsen
CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion
title CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion
title_full CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion
title_fullStr CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion
title_full_unstemmed CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion
title_short CHILD syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion
title_sort child syndrome: successful treatment of skin lesions with topical lovastatin and cholesterol lotion
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668949/
https://www.ncbi.nlm.nih.gov/pubmed/31365666
http://dx.doi.org/10.1590/abd1806-4841.20198789
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