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High-affinity free ubiquitin sensors for quantifying ubiquitin homeostasis and deubiquitination
Ubiquitin (Ub) conjugation is an essential post-translational modification that affects nearly all proteins in eukaryotes. The functions and mechanisms of ubiquitination are areas of extensive study, and yet the dynamics and regulation of even free (i.e., unconjugated) Ub are poorly understood. A ma...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669086/ https://www.ncbi.nlm.nih.gov/pubmed/31308549 http://dx.doi.org/10.1038/s41592-019-0469-9 |